PSB-1011 is a competitive inhibitor of the rat P2X2 receptor with a Ki value of 79 nM. PSB-1011 exhibited a competitive mechanism of action (pA(2) 7.49). It was >100-fold selective versus P2X4, P2X7, and several investigated P2Y receptor subtypes (P2Y(2,4,6,12)); selectivity versus P2X1 and P2X3 receptors was moderate (>5-fold). PSB-1011 was >13-fold more potent at the homomeric P2X2 than at the heteromeric P2X2/3 receptor.
MedKoo Cat#: 530558
Name: PSB-1011 sodium
CAS#: 4499-01-8 (sodium)
Chemical Formula: C23H12Cl2N6Na2O8S2
Exact Mass:
Molecular Weight: 681.38
Elemental Analysis: C, 40.54; H, 1.78; Cl, 10.41; N, 12.33; Na, 6.75; O, 18.78; S, 9.41
The following data is based on the product molecular weight 681.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
