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MedKoo Cat#: 128057 | Name: BE-18591

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BE-18591 is a new H+/Cl− symport ionophore that inhibits immunoproliferation and gastritis.

Chemical Structure

BE-18591
BE-18591
CAS#147138-01-0

Theoretical Analysis

MedKoo Cat#: 128057

Name: BE-18591

CAS#: 147138-01-0

Chemical Formula: C22H35N3O

Exact Mass: 357.2780

Molecular Weight: 357.54

Elemental Analysis: C, 73.91; H, 9.87; N, 11.75; O, 4.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BE-18591; BE 18591; BE18591
IUPAC/Chemical Name
(E)-N-((4'-methoxy-1H,5'H-[2,2'-bipyrrol]-5'-ylidene)methyl)dodecan-1-amine
InChi Key
FDQXCPYGFLFWFX-DYTRJAOYSA-N
InChi Code
InChI=1S/C22H35N3O/c1-3-4-5-6-7-8-9-10-11-12-15-23-18-21-22(26-2)17-20(25-21)19-14-13-16-24-19/h13-14,16-18,23-24H,3-12,15H2,1-2H3/b21-18+
SMILES Code
CCCCCCCCCCCCN/C=C(C(OC)=C1)/N=C1C2=CC=CN2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 357.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tanigaki K, Sato T, Tanaka Y, Ochi T, Nishikawa A, Nagai K, Kawashima H, Ohkuma S. BE-18591 as a new H(+)/Cl(-) symport ionophore that inhibits immunoproliferation and gastritis. FEBS Lett. 2002 Jul 31;524(1-3):37-42. doi: 10.1016/s0014-5793(02)02996-4. PMID: 12135738. 2: Grenade NL, Chiriac DS, Pasternak ARO, Babulic JL, Rowland BE, Howe GW, Ross AC. Discovery of a Tambjamine Gene Cluster in Streptomyces Suggests Convergent Evolution in Bipyrrole Natural Product Biosynthesis. ACS Chem Biol. 2023 Feb 17;18(2):223-229. doi: 10.1021/acschembio.2c00685. Epub 2023 Jan 4. PMID: 36599132. 3: Pinkerton DM, Banwell MG, Willis AC. Total syntheses of tambjamines C, E, F, G, H, I and J, BE-18591, and a related alkaloid from the marine bacterium Pseudoalteromonas tunicata. Org Lett. 2007 Nov 22;9(24):5127-30. doi: 10.1021/ol7024313. Epub 2007 Oct 27. PMID: 17963401. 4: Pinkerton DM, Banwell MG, Garson MJ, Kumar N, de Moraes MO, Cavalcanti BC, Barros FW, Pessoa C. Antimicrobial and cytotoxic activities of synthetically derived tambjamines C and E - J, BE-18591, and a related alkaloid from the marine bacterium Pseudoalteromonas tunicata. Chem Biodivers. 2010 May;7(5):1311-24. doi: 10.1002/cbdv.201000030. PMID: 20491087. 5: Kojiri K, Nakajima S, Suzuki H, Okura A, Suda H. A new antitumor substance, BE-18591, produced by a streptomycete. I. Fermentation, isolation, physico- chemical and biological properties. J Antibiot (Tokyo). 1993 Dec;46(12):1799-803. doi: 10.7164/antibiotics.46.1799. PMID: 8294236. 6: Nakajima S, Kojiri K, Suda H. A new antitumor substance, BE-18591, produced by a streptomycete. II. Structure determination. J Antibiot (Tokyo). 1993 Dec;46(12):1894-6. doi: 10.7164/antibiotics.46.1894. PMID: 8294249.