Synonym
Clidanac; Britai; Clidanaco; TAI-284; TAI 284; TAI284; dl-TAI 284; Indanal.
IUPAC/Chemical Name
6-Chloro-5-cyclohexyl-2,3-dihydro-1H-indene-1-carboxylic acid
InChi Key
OIRAEJWYWSAQNG-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H19ClO2/c17-15-9-13-11(6-7-12(13)16(18)19)8-14(15)10-4-2-1-3-5-10/h8-10,12H,1-7H2,(H,18,19)
SMILES Code
O=C(C1CCC2=C1C=C(Cl)C(C3CCCCC3)=C2)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
278.78
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kawai K, Shiojiri H, Fukushima H, Nozawa Y, Hasegawa J, Nozaki M, Tsurumi K, Fujimura H. The effect of clidanac, a potent anti-inflammatory drug, on mitochondrial respiration: a consideration on the uncoupling activity of optical enantiomers. Res Commun Chem Pathol Pharmacol. 1984 Sep;45(3):399-406. PubMed PMID: 6334337.
2: Boettcher I, Elger W, Kirsch G, Siegmund F, Wachtel H. Nonsteroidal antiinflammatory agents. 14. Synthesis and pharmacological profile of 6-chloro-5-(cyclopentylmethyl)indan-1-carboxylic acid. J Med Chem. 1984 Mar;27(3):413-4. PubMed PMID: 6608000.
3: Hasegawa J, Nozaki M, Fujimura H. [The effects of various drugs on the binding site of bilirubin in serum albumin]. Nihon Yakurigaku Zasshi. 1984 Jan;83(1):79-83. Japanese. PubMed PMID: 6714852.
4: Hutt AJ, Caldwell J. The metabolic chiral inversion of 2-arylpropionic acids--a novel route with pharmacological consequences. J Pharm Pharmacol. 1983 Nov;35(11):693-704. Review. PubMed PMID: 6139449.
5: Imai H, Niwa M, Nozaki M, Tsurumi K, Fujimura H. [Influence of indomethacin and clidanac on the blood pressure lowering effect of beta-blockers]. Nihon Yakurigaku Zasshi. 1983 Jan;81(1):13-20. Japanese. PubMed PMID: 6133820.
6: Tamura S, Kuzuna S, Kawai K, Kishimoto S. Optical isomerization of R(-)-clidanac to the biologically active S(+)-isomer in guinea-pigs. J Pharm Pharmacol. 1981 Nov;33(11):701-6. PubMed PMID: 6118407.
7: Tamura S, Kuzuna S, Kawai K. Inhibition of prostaglandin biosynthesis by clidanac and related compounds: structural and conformational requirements for PG synthetase inhibition. J Pharm Pharmacol. 1981 Jan;33(1):29-32. PubMed PMID: 6114148.
8: Rosazza JP, Smith RV. Microbial models for drug metabolism. Adv Appl Microbiol. 1979;25:169-208. Review. PubMed PMID: 397736.
