MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 532180 | Name: MG149
Featured New

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MG149 is a potent and selective inhibitor of the MYST family (Tip60 and MOZ) of histone acetyltransferase (HAT). MG149 is a novel anacardic acid analog. In addition, it effectively inhibits acetyltransferase activity of HeLa cells nuclear extracts.

Chemical Structure

MG149
MG149
CAS#1243583-85-8

Theoretical Analysis

MedKoo Cat#: 532180

Name: MG149

CAS#: 1243583-85-8

Chemical Formula: C22H28O3

Exact Mass: 340.2038

Molecular Weight: 340.46

Elemental Analysis: C, 77.61; H, 8.29; O, 14.10

Price and Availability

Size Price Availability Quantity
25mg USD 450.00 2 Weeks
50mg USD 750.00 2 Weeks
100mg USD 1,250.00 2 Weeks
500mg USD 2,850.00 2 Weeks
1g USD 4,250.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
1243583-85-8
Synonym
MG149; MG 149; MG-149.
IUPAC/Chemical Name
2-[2-(4-heptylphenyl)ethyl]-6-hydroxybenzoic acid
InChi Key
WBHQYBZRTAEHRR-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H28O3/c1-2-3-4-5-6-8-17-11-13-18(14-12-17)15-16-19-9-7-10-20(23)21(19)22(24)25/h7,9-14,23H,2-6,8,15-16H2,1H3,(H,24,25)
SMILES Code
O=C(O)C1=C(O)C=CC=C1CCC2=CC=C(CCCCCCC)C=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
MG149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50= 47 uM).
In vitro activity:
H9c2 cells were pretreated for 24 h with the MOF inhibitor MG149 after 4 Gy irradiation, followed by assessment of cell proliferation, injury, and apoptosis. MG149 suppressed the proliferation inhibition, reduction of mitochondrial membrane potential, ROS production, and cell apoptosis. MG149 may promote the survival of H9c2 cells via inhibition of MOF-mediated p53K120 acetylation in response to X-ray radiation-induced apoptosis. Reference: Radiat Res. 2022 Dec 1;198(6):590-598. https://pubmed.ncbi.nlm.nih.gov/36481803/
In vivo activity:
This study reports that systemic deletion of MRTF-A or inhibition of MRTF-A activity with CCG-1423 significantly attenuated AKI (acute kidney injury) in mice induced by either ischemia-reperfusion or LPS injection. In addition, administration of a MYST1 inhibitor MG149 alleviated AKI in mice. Reference: Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3109-3121. https://pubmed.ncbi.nlm.nih.gov/29908908/
Solvent mg/mL mM comments
Solubility
DMSO 66.0 193.85
Ethanol 49.0 143.92
Ethanol:PBS (pH 7.2) (1:3) 0.3 0.73
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 340.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Nie Q, Huan X, Kang J, Yin J, Zhao J, Li Y, Zhang Z. MG149 Inhibits MOF-Mediated p53 Acetylation to Attenuate X-Ray Radiation-Induced Apoptosis in H9c2 Cells. Radiat Res. 2022 Dec 1;198(6):590-598. doi: 10.1667/RADE-22-00049.1. PMID: 36481803. 2. Ghizzoni M, Wu J, Gao T, Haisma HJ, Dekker FJ, George Zheng Y. 6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site. Eur J Med Chem. 2012 Jan;47(1):337-44. doi: 10.1016/j.ejmech.2011.11.001. Epub 2011 Nov 10. PMID: 22100137; PMCID: PMC3399519. 3. Liu L, Wu X, Xu H, Yu L, Zhang X, Li L, Jin J, Zhang T, Xu Y. Myocardin-related transcription factor A (MRTF-A) contributes to acute kidney injury by regulating macrophage ROS production. Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3109-3121. doi: 10.1016/j.bbadis.2018.05.026. Epub 2018 Jun 14. PMID: 29908908.
In vitro protocol:
1. Nie Q, Huan X, Kang J, Yin J, Zhao J, Li Y, Zhang Z. MG149 Inhibits MOF-Mediated p53 Acetylation to Attenuate X-Ray Radiation-Induced Apoptosis in H9c2 Cells. Radiat Res. 2022 Dec 1;198(6):590-598. doi: 10.1667/RADE-22-00049.1. PMID: 36481803. 2. Ghizzoni M, Wu J, Gao T, Haisma HJ, Dekker FJ, George Zheng Y. 6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site. Eur J Med Chem. 2012 Jan;47(1):337-44. doi: 10.1016/j.ejmech.2011.11.001. Epub 2011 Nov 10. PMID: 22100137; PMCID: PMC3399519.
In vivo protocol:
1. Liu L, Wu X, Xu H, Yu L, Zhang X, Li L, Jin J, Zhang T, Xu Y. Myocardin-related transcription factor A (MRTF-A) contributes to acute kidney injury by regulating macrophage ROS production. Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3109-3121. doi: 10.1016/j.bbadis.2018.05.026. Epub 2018 Jun 14. PMID: 29908908.
1: Legartová S, Stixová L, Strnad H, Kozubek S, Martinet N, Dekker FJ, Franek M, Bártová E. Basic nuclear processes affected by histone acetyltransferases and histone deacetylase inhibitors. Epigenomics. 2013 Aug;5(4):379-96. doi: 10.2217/epi.13.38. PubMed PMID: 23895652. 2: Shimizu T, Kida Y, Kuwano K. A triacylated lipoprotein from Mycoplasma genitalium activates NF-kappaB through Toll-like receptor 1 (TLR1) and TLR2. Infect Immun. 2008 Aug;76(8):3672-8. doi: 10.1128/IAI.00257-08. PubMed PMID: 18474641; PubMed Central PMCID: PMC2493199.