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MedKoo Cat#: 130419 | Name: MH-3

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MH-3 is a melanin-concentrating hormone receptor-1 (MCH-R1) ligand with an IC50 of 7 nM.

Chemical Structure

MH-3
MH-3
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130419

Name: MH-3

CAS#: N/A

Chemical Formula: C24H26N2O3

Exact Mass: 390.1943

Molecular Weight: 390.48

Elemental Analysis: C, 73.82; H, 6.71; N, 7.17; O, 12.29

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MH-3; MH3; MH 3
IUPAC/Chemical Name
(R)-3,5-dimethoxy-N-(1-(naphthalen-2-ylmethyl)pyrrolidin-3-yl)benzamide
InChi Key
IWBPLOCOVVLUIE-OAQYLSRUSA-N
InChi Code
InChI=1S/C24H26N2O3/c1-28-22-12-20(13-23(14-22)29-2)24(27)25-21-9-10-26(16-21)15-17-7-8-18-5-3-4-6-19(18)11-17/h3-8,11-14,21H,9-10,15-16H2,1-2H3,(H,25,27)/t21-/m1/s1
SMILES Code
O=C(N[C@H]1CN(CC2=CC=C3C=CC=CC3=C2)CC1)C4=CC(OC)=CC(OC)=C4
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 390.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Helal MA, Chittiboyina AG, Avery MA. Structure-based design of novel melanin-concentrating hormone receptor-1 ligands based on saturated nitrogen-containing heterocycles. Bioorg Med Chem Lett. 2023 Mar 15;84:129194. doi: 10.1016/j.bmcl.2023.129194. Epub 2023 Feb 20. PMID: 36813053.