L-759,633 is high affinity, selective CB2 receptor agonist (Ki values are 6.4 and 1043 nM for CB2 and CB1 receptors respectively). L-759,633 potently inhibits forskolin-stimulated cAMP production via CB2 receptors expressed in CHO cells (EC50 = 8.1 nM).
MedKoo Cat#: 532085
Name: L-759,633
CAS#: 174627-50-0
Chemical Formula: C26H40O2
Exact Mass: 384.3028
Molecular Weight: 384.60
Elemental Analysis: C, 81.20; H, 10.48; O, 8.32
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| Ethanol | 20.0 | 52.00 | |
| PBS (pH 7.2) | 0.3 | 0.65 |
The following data is based on the product molecular weight 384.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
