MedKoo Cat#: 466028 | Name: Suomilide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Suomilide is a natural potent trypsin inhibitor, inhibiting human trypsin-2 and -3 with IC50 values of 4.7 and 11.5 nM, respectively, while trypsin-1 being inhibited with an IC50 of 104 nM.

Chemical Structure

Suomilide
Suomilide
CAS#195256-59-8

Theoretical Analysis

MedKoo Cat#: 466028

Name: Suomilide

CAS#: 195256-59-8

Chemical Formula: C45H73N7O19S

Exact Mass: 1047.4682

Molecular Weight: 1048.17

Elemental Analysis: C, 51.57; H, 7.02; N, 9.35; O, 29.00; S, 3.06

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Suomilide;
IUPAC/Chemical Name
((2R,3S,4S,5R,6S)-6-((4-((2-(1-carbamimidoyl-2,5-dihydro-1H-pyrrol-3-yl)ethyl)carbamoyl)-10-hydroxy-5-((2-methoxy-3-(sulfooxy)propanoyl)-D-alloisoleucyl)-2-oxooctahydro-2H-6,9a-methanooxazolo[4,5-c]azocin-8-yl)oxy)-5-(hexanoyloxy)-3,4-dihydroxytetrahydro-2H-pyran-2-yl)methyl hexanoate
InChi Key
KAKUZTRQMKJXIH-XQKBIKNYSA-N
InChi Code
InChI=1S/C45H73N7O19S/c1-6-9-11-13-30(53)66-22-28-34(55)35(56)36(70-31(54)14-12-10-7-2)42(69-28)68-26-19-27-38(57)45(20-26)37(50-44(61)71-45)33(40(59)48-17-15-25-16-18-51(21-25)43(46)47)52(27)41(60)32(24(4)8-3)49-39(58)29(65-5)23-67-72(62,63)64/h16,24,26-29,32-38,42,55-57H,6-15,17-23H2,1-5H3,(H3,46,47)(H,48,59)(H,49,58)(H,50,61)(H,62,63,64)/t24-,26?,27?,28+,29?,32+,33?,34+,35-,36+,37?,38?,42-,45?/m0/s1
SMILES Code
CCCCCC(OC[C@H]1O[C@H](OC(C2)CC3N(C([C@H](NC(C(OC)COS(=O)(O)=O)=O)[C@@H](C)CC)=O)C(C(NCCC4=CCN(C(N)=N)C4)=O)C(C2(C3O)O5)NC5=O)[C@H](OC(CCCCC)=O)[C@@H](O)[C@@H]1O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,048.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ahmed MN, Wahlsten M, Jokela J, Nees M, Stenman UH, Alvarenga DO, Strandin T, Sivonen K, Poso A, Permi P, Metsä-Ketelä M, Koistinen H, Fewer DP. Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products. ACS Chem Biol. 2021 Nov 19;16(11):2537-2546. doi: 10.1021/acschembio.1c00611. Epub 2021 Oct 18. PMID: 34661384; PMCID: PMC8609519. 2: Schindler CS, Carreira EM. Rapid formation of complexity in the total synthesis of natural products enabled by oxabicyclo[2.2.1]heptene building blocks. Chem Soc Rev. 2009 Nov;38(11):3222-41. doi: 10.1039/b915448p. Epub 2009 Sep 30. PMID: 19847353. 3: Schindler CS, Stephenson CR, Carreira EM. Enantioselective synthesis of the core of banyaside, suomilide, and spumigin HKVV. Angew Chem Int Ed Engl. 2008;47(46):8852-5. doi: 10.1002/anie.200803655. PMID: 18855958.