Synonym
CORM-401; CORM 401; CORM401.
IUPAC/Chemical Name
Manganate(1-), tetracarbonyl[N-(dithiocarboxy-κS,κS')-N-methylglycinato(2-)]-, hydrogen (1:1), (OC-6-22)-
InChi Key
PBEOVQBORDYRJY-UHFFFAOYSA-M
InChi Code
InChI=1S/C4H7NO2S2.4CO.Mn/c1-5(4(8)9)2-3(6)7;4*1-2;/h2H2,1H3,(H,6,7)(H,8,9);;;;;/q;4*+1;-3/p-1
SMILES Code
OC(CN(C)C1=S=[Mn-4]([C+]=O)([C+]=O)([C+]=O)([C+]=O)S1)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Carbon monoxide (CO) is generated by heme oxygenase-1 (HO-1) and displays important signaling, anti-apoptotic and anti-inflammatory activities, indicating that pharmacological agents mimicking its action may have therapeutic benefit.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
331.20
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kaczara P, Motterlini R, Rosen GM, Augustynek B, Bednarczyk P, Szewczyk A, Foresti R, Chlopicki S. Carbon monoxide released by CORM-401 uncouples mitochondrial respiration and inhibits glycolysis in endothelial cells: A role for mitoBKCa channels. Biochim Biophys Acta. 2015 Oct;1847(10):1297-309. doi: 10.1016/j.bbabio.2015.07.004. PubMed PMID: 26185029.
2: Babu D, Leclercq G, Motterlini R, Lefebvre RA. Differential Effects of CORM-2 and CORM-401 in Murine Intestinal Epithelial MODE-K Cells under Oxidative Stress. Front Pharmacol. 2017 Feb 8;8:31. doi: 10.3389/fphar.2017.00031. PubMed PMID: 28228725; PubMed Central PMCID: PMC5296622.
3: Fayad-Kobeissi S, Ratovonantenaina J, Dabiré H, Wilson JL, Rodriguez AM, Berdeaux A, Dubois-Randé JL, Mann BE, Motterlini R, Foresti R. Vascular and angiogenic activities of CORM-401, an oxidant-sensitive CO-releasing molecule. Biochem Pharmacol. 2016 Feb 15;102:64-77. doi: 10.1016/j.bcp.2015.12.014. PubMed PMID: 26721585.
4: Kaczara P, Motterlini R, Kus K, Zakrzewska A, Abramov AY, Chlopicki S. Carbon monoxide shifts energetic metabolism from glycolysis to oxidative phosphorylation in endothelial cells. FEBS Lett. 2016 Oct;590(20):3469-3480. doi: 10.1002/1873-3468.12434. PubMed PMID: 27670394.
5: Wilson JL, Bouillaud F, Almeida AS, Vieira HL, Ouidja MO, Dubois-Randé JL, Foresti R, Motterlini R. Carbon monoxide reverses the metabolic adaptation of microglia cells to an inflammatory stimulus. Free Radic Biol Med. 2017 Mar;104:311-323. doi: 10.1016/j.freeradbiomed.2017.01.022. PubMed PMID: 28108277.
6: Vummaleti SV, Branduardi D, Masetti M, De Vivo M, Motterlini R, Cavalli A. Theoretical insights into the mechanism of carbon monoxide (CO) release from CO-releasing molecules. Chemistry. 2012 Jul 23;18(30):9267-75. doi: 10.1002/chem.201103617. PubMed PMID: 22730163.