MedKoo Cat#: 461929 | Name: Scillaren A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Scillaren A is a a crystalline steroidal glycoside from Scilla maritima.

Chemical Structure

Scillaren A
Scillaren A
CAS#124-99-2

Theoretical Analysis

MedKoo Cat#: 461929

Name: Scillaren A

CAS#: 124-99-2

Chemical Formula: C36H52O13

Exact Mass: 692.3408

Molecular Weight: 692.79

Elemental Analysis: C, 62.41; H, 7.57; O, 30.02

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Scillaren A; Scillaglykosid A; Scillaren A; Transvaalin;
IUPAC/Chemical Name
5-((3S,8R,9S,10R,13R,14S,17R)-3-(((2R,3R,4S,5R,6S)-3,4-dihydroxy-6-methyl-5-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-14-hydroxy-10,13-dimethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one
InChi Key
NXJOCELNFPGKIV-ARHXXGKOSA-N
InChi Code
InChI=1S/C36H52O13/c1-17-31(49-33-29(42)27(40)26(39)24(15-37)48-33)28(41)30(43)32(46-17)47-20-8-11-34(2)19(14-20)5-6-23-22(34)9-12-35(3)21(10-13-36(23,35)44)18-4-7-25(38)45-16-18/h4,7,14,16-17,20-24,26-33,37,39-44H,5-6,8-13,15H2,1-3H3/t17-,20-,21+,22-,23+,24+,26+,27-,28-,29+,30+,31-,32-,33-,34-,35+,36-/m0/s1
SMILES Code
O=C1C=CC([C@H]2CC[C@]3(O)[C@]4([H])CCC5=C[C@@H](O[C@H]6[C@H](O)[C@H](O)[C@@H](O[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7)[C@H](C)O6)CC[C@]5(C)[C@@]4([H])CC[C@]23C)=CO1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 692.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ferrer M, Basarte JC, Fernandez M, Fos D, Vega FA. [Densitometric determination of proscillaridin A, scillaren A and scilliroside]. Farmaco Prat. 1980 Jan;35(1):32-46. Spanish. PubMed PMID: 7449933. 2: HOFFMANN HJ, WOLLENBERGER A. [Examination of hexahydroscillaren A & allocymarin as possible antagonists of scillaren A & cymarin on isolated heart]. Acta Biol Med Ger. 1959;2(1):94-9. German. PubMed PMID: 13626422. 3: Balbaa SI, Khafagy SM, Khayyal SE, Girgis AN. TLC-spectrophotometric assay of the main glycosides of red squill, a specific rodenticide. J Nat Prod. 1979 Sep-Oct;42(5):522-4. PubMed PMID: 521820. 4: Jha S, Sen S. Quantitation of Principal Bufadienolides in Different Cytotypes of Urginea indica. Planta Med. 1983 Jan;47(1):43-5. PubMed PMID: 17405091. 5: Robinson JW. The difference in sensitivity to cardiac steroids of (Na++K+)-stimulated ATPase and amino acid transport in the intestinal mucosa of the rat and other species. J Physiol. 1970 Jan;206(1):41-60. PubMed PMID: 4250728; PubMed Central PMCID: PMC1348585. 6: Majinda RR, Waigh RD, Waterman PG. Bufadienolides and other constituents of Urginea sanguinea. Planta Med. 1997 Apr;63(2):188-90. PubMed PMID: 9140237. 7: Dias C, Borralho Graça JA, Lurdes Gonçalves M. Scilla maderensis, TLC screening and positive inotropic effect of bulb extracts. J Ethnopharmacol. 2000 Aug;71(3):487-92. PubMed PMID: 10940588. 8: Krenn L, Ferth R, Robien W, Kopp B. Bufadienolides from Urginea maritima sensu strictu. Planta Med. 1991 Dec;57(6):560-5. PubMed PMID: 17226202. 9: Heidenreich O, Baumeister L, Fülgraff G, Hahnege V, Laaff H. [Comparative studies on the diuretic effect and acute toxicity of g-strophanthin, scillaren and proscillaridin in dogs]. Arch Int Pharmacodyn Ther. 1967 Mar;166(1):1-10. German. PubMed PMID: 6068059. 10: CARPI A, KONZETT H, CERLETTI A. [Effect of squill on the chemoreceptors of the carotid body of the dog]. Arch Int Pharmacodyn Ther. 1957 Feb 1;109(3-4):369-76. German. PubMed PMID: 13425728.