LTX-401 is an immunotherapeutic agent and an oncolytic amino acid derivative with potential immunogenic properties. LTX-401 Induces DAMP Release in Melanoma Cells and Causes Complete Regression of B16 Melanoma. The cytotoxic effect of LTX-401 was attenuated by the double knockout of BAX and BAK, as well as the mitophagy-enforced depletion of mitochondria, yet was refractory to caspase inhibition. LTX-401 induced all major hallmarks of immunogenic cell death detectable with biosensor cell lines including calreticulin exposure, ATP release, HMGB1 exodus and a type-1 interferon response. Moreover, LTX-401-treated tumors manifested a strong lymphoid infiltration. LTX-401 can stimulate immunogenic cell death through a pathway in which Golgi-localized LTX-401 operates upstream of mitochondrial membrane permeabilization.
MedKoo Cat#: 206794
Name: LTX-401 HCl
CAS#: 1398051-86-9 (2HCl)
Chemical Formula: C23H35Cl2N3O
Exact Mass:
Molecular Weight: 440.45
Elemental Analysis: C, 62.72; H, 8.01; Cl, 16.10; N, 9.54; O, 3.63
The following data is based on the product molecular weight 440.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
