Pruvanserin HCl | CAS#443144-27-2 | CAS#443144-26-1

MedKoo Cat#: 529103 | Name: Pruvanserin HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pruvanserin HCl a 5-HT2A antagonist potentially for the treatment of insomnia.

Chemical Structure

Pruvanserin HCl

CAS#443144-27-2 (HCl)

Theoretical Analysis

MedKoo Cat#: 529103

Name: Pruvanserin HCl

CAS#: 443144-27-2 (HCl)

Chemical Formula: C22H22ClFN4O

Exact Mass: 412.1470

Molecular Weight: 412.89

Elemental Analysis: C, 64.00; H, 5.37; Cl, 8.59; F, 4.60; N, 13.57; O, 3.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

443144-26-1 (free base) 443144-27-2 (HCl)

Synonym

EMD-281014; LSN-2422347; LY-2420586; LY-2422347; EMD281014; LSN2422347; LY2420586; LY2422347; EMD 281014; LSN 2422347; LY 2420586; LY 2422347; Pruvanserin HCl; Pruvanserin Hydrochloride;

IUPAC/Chemical Name

7-(4-(4-fluorophenethyl)piperazine-1-carbonyl)-1H-indole-3-carbonitrile hydrochloride

InChi Key

UYGNZRVLPYZLTF-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H21FN4O.ClH/c23-18-6-4-16(5-7-18)8-9-26-10-12-27(13-11-26)22(28)20-3-1-2-19-17(14-24)15-25-21(19)20;/h1-7,15,25H,8-13H2;1H

SMILES Code

FC1=CC=C(CCN2CCN(C(C3=CC=CC4=C3NC=C4C#N)=O)CC2)C=C1.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 412.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Mixcoatl-Zecuatl T, Jolivalt CG. A spinal mechanism of action for duloxetine in a rat model of painful diabetic neuropathy. Br J Pharmacol. 2011 Sep;164(1):159-69. doi: 10.1111/j.1476-5381.2011.01334.x. PubMed PMID: 21410686; PubMed Central PMCID: PMC3171868. 2: Monti JM. Serotonin control of sleep-wake behavior. Sleep Med Rev. 2011 Aug;15(4):269-81. doi: 10.1016/j.smrv.2010.11.003. Review. PubMed PMID: 21459634. 3: Teegarden BR, Al Shamma H, Xiong Y. 5-HT(2A) inverse-agonists for the treatment of insomnia. Curr Top Med Chem. 2008;8(11):969-76. PubMed PMID: 18673166.