MedKoo Cat#: 574272 | Name: Fosciclopirox
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fosciclopirox(CPX-POM) selectively delivers the active metabolite, Ciclopirox (CPX) that targets γ-secretase complex (Presenilin 1 and Nicastrin)2.

Chemical Structure

Fosciclopirox
Fosciclopirox
CAS#1380539-06-9 (free base)

Theoretical Analysis

MedKoo Cat#: 574272

Name: Fosciclopirox

CAS#: 1380539-06-9 (free base)

Chemical Formula: C13H20NO6P

Exact Mass: 317.1028

Molecular Weight: 317.28

Elemental Analysis: C, 49.21; H, 6.35; N, 4.41; O, 30.26; P, 9.76

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
10mg USD 850.00 2 Weeks
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Synonym
Fosciclopirox; Ciclopirox-pom; CPX-POM; CPXPOM; CPX POM;
IUPAC/Chemical Name
[(6-cyclohexyl-4-methyl-2-oxopyridin-1(2H)-yl)oxy]methyl dihydrogen phosphate
InChi Key
NTKBXPWLNROYPE-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H20NO6P/c1-10-7-12(11-5-3-2-4-6-11)14(13(15)8-10)19-9-20-21(16,17)18/h7-8,11H,2-6,9H2,1H3,(H2,16,17,18)
SMILES Code
O=P(O)(OCON1C(C2CCCCC2)=CC(C)=CC1=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 317.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Weir SJ, Wood R, Schorno K, Brinker AE, Ramamoorthy P, Heppert K, Rajewski L, Tanol M, Ham T, McKenna MJ, McCulloch W, Dalton M, Reed GA, Jensen RA, Baltezor MJ, Anant S, Taylor JA 3rd. Preclinical Pharmacokinetics of Fosciclopirox, a Novel Treatment of Urothelial Cancers, in Rats and Dogs. J Pharmacol Exp Ther. 2019 Aug;370(2):148-159. doi: 10.1124/jpet.119.257972. Epub 2019 May 21. PubMed PMID: 31113837; PubMed Central PMCID: PMC6614794.