Implitapide | CAS#177469-96-4 | MTTP inhibitor

MedKoo Cat#: 529321 | Name: Implitapide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Implitapide is a MTTP inhibitor potentially for the treatment of hypercholesterolemia.

Chemical Structure

Implitapide

CAS#177469-96-4

Theoretical Analysis

MedKoo Cat#: 529321

Name: Implitapide

CAS#: 177469-96-4

Chemical Formula: C35H37N3O2

Exact Mass: 531.2886

Molecular Weight: 531.70

Elemental Analysis: C, 79.06; H, 7.01; N, 7.90; O, 6.02

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

AEGR-427; BAY-13-9952; BAY-139952; AEGR427; BAY139952; AEGR 427; BAY 13 9952; BAY 139952

IUPAC/Chemical Name

(S)-2-cyclopentyl-2-(4-((2,4-dimethyl-9H-pyrido[2,3-b]indol-9-yl)methyl)phenyl)-N-((R)-2-hydroxy-1-phenylethyl)acetamide

InChi Key

KIMRCJZMVARVSU-DITALETJSA-N

InChi Code

InChI=1S/C35H37N3O2/c1-23-20-24(2)36-34-32(23)29-14-8-9-15-31(29)38(34)21-25-16-18-28(19-17-25)33(27-12-6-7-13-27)35(40)37-30(22-39)26-10-4-3-5-11-26/h3-5,8-11,14-20,27,30,33,39H,6-7,12-13,21-22H2,1-2H3,(H,37,40)/t30-,33-/m0/s1

SMILES Code

O=C(N[C@@H](CO)C1=CC=CC=C1)[C@H](C2=CC=C(CN3C4=NC(C)=CC(C)=C4C5=C3C=CC=C5)C=C2)C6CCCC6

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 531.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ueshima K, Akihisa-Umeno H, Nagayoshi A, Takakura S, Matsuo M, Mutoh S. Implitapide, a microsomal triglyceride transfer protein inhibitor, reduces progression of atherosclerosis in apolipoprotein E knockout mice fed a Western-type diet: involvement of the inhibition of postprandial triglyceride elevation. Biol Pharm Bull. 2005 Feb;28(2):247-52. PubMed PMID: 15684478. 2: Shiomi M, Ito T. MTP inhibitor decreases plasma cholesterol levels in LDL receptor-deficient WHHL rabbits by lowering the VLDL secretion. Eur J Pharmacol. 2001 Nov 9;431(1):127-31. PubMed PMID: 11716851. 3: Davidson MH. Novel nonstatin strategies to lower low-density lipoprotein cholesterol. Curr Atheroscler Rep. 2009 Jan;11(1):67-70. Review. PubMed PMID: 19080731. 4: Pahan K. Lipid-lowering drugs. Cell Mol Life Sci. 2006 May;63(10):1165-78. Review. PubMed PMID: 16568248; PubMed Central PMCID: PMC1986656. 5: Iglesias P, Díez JJ. New drugs for the treatment of hypercholesterolaemia. Expert Opin Investig Drugs. 2003 Nov;12(11):1777-89. Review. PubMed PMID: 14585054. 6: Bayes M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2002 Jan-Feb;24(1):37-55. PubMed PMID: 11980386.