IMP-1700 is an inhibitor of bacterial DNA repair. It potentiates the activity of the quinolone antibiotic ciprofloxacin against methicillin-resistant S. aureus (MRSA) with a combination index value of 0.7. IMP-1700 inhibits the ciprofloxacin-induced bacterial SOS response, a process that repairs DNA damage, in a reporter assay in a concentration-dependent manner. It is also active against E. coli, as well as methicillin-resistant and -sensitive S. aureus, when used alone (EC50s = 0.5, 0.21, and 3.8 µM, respectively).
MedKoo Cat#: 533326
Name: IMP-1700
CAS#: 1458674-25-3
Chemical Formula: C25H22F4N4O3S
Exact Mass: 534.1349
Molecular Weight: 534.53
Elemental Analysis: C, 56.18; H, 4.15; F, 14.22; N, 10.48; O, 8.98; S, 6.00
The following data is based on the product molecular weight 534.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
