HL16 | CETP Inhibitor

MedKoo Cat#: 565140 | Name: HL16

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HL16 is a highly potent CETP inhibitor in vitro, which exhibits favorable HDL-C enhancement and LDL-C reduction in vivo by hamster. HL16 was demonstrated to occupy the CETP binding site and form interactions with the key amino acid residues.

Chemical Structure

HL16

CAS#NONE

Theoretical Analysis

MedKoo Cat#: 565140

Name: HL16

CAS#: NONE

Chemical Formula: C35H36FN3O4

Exact Mass: 581.2690

Molecular Weight: 581.69

Elemental Analysis: C, 72.27; H, 6.24; F, 3.27; N, 7.22; O, 11.00

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

HL-16; HL 16; HL16

IUPAC/Chemical Name

4-(4-{3-[(4-Fluoro-benzyl)-(3-phenoxy-phenyl)-amino]-propionyl}-piperazin-1-yl)-benzoic acid ethyl ester

InChi Key

QZPYNMNJEWKZBN-UHFFFAOYSA-N

InChi Code

InChI=1S/C35H36FN3O4/c1-2-42-35(41)28-13-17-30(18-14-28)37-21-23-38(24-22-37)34(40)19-20-39(26-27-11-15-29(36)16-12-27)31-7-6-10-33(25-31)43-32-8-4-3-5-9-32/h3-18,25H,2,19-24,26H2,1H3

SMILES Code

O=C(OCC)C1=CC=C(N2CCN(C(CCN(CC3=CC=C(F)C=C3)C4=CC=CC(OC5=CC=CC=C5)=C4)=O)CC2)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 581.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhao D, Xie H, Bai C, Liu C, Hao C, Zhao S, Yuan H, Luo C, Wang J, Lin B, Zheng J, Cheng M. Design, synthesis and biological evaluation of N,N-3-phenyl-3-benzylaminopropanamide derivatives as novel cholesteryl ester transfer protein inhibitor. Bioorg Med Chem. 2016 Apr 15;24(8):1589-97. doi: 10.1016/j.bmc.2015.12.010. Epub 2015 Dec 8. PubMed PMID: 27010500. 2: Xie H, Li Y, Bai C, Wang R, Liu C, Hao C, Lin B, Cheng M, Zhao D. Discovery of novel N,N-3-phenyl-3-benzylaminopropionanilides as potent inhibitors of cholesteryl ester transfer protein in vivo. Bioorg Med Chem. 2016 Apr 15;24(8):1811-8. doi: 10.1016/j.bmc.2016.03.002. Epub 2016 Mar 2. PubMed PMID: 26993745.