DNS-8254 is a potent and selective Phosphodiesterase 2 (PDE2) Inhibitor for the Treatment of Memory Disorders (hPDE2a IC50 = 8 nM, Rat Cl-int = 25.6 uL/min/mg). In vivo, DNS-8254 demonstrated significant memory enhancing effects in a rat model of novel object recognition. DNS-8254 may be a useful tool to explore the pharmacology of selective PDE2a inhibition.
MedKoo Cat#: 530515
Name: DNS-8254
CAS#: 1821107-98-5
Chemical Formula: C18H15BrF3N5O
Exact Mass: 453.0412
Molecular Weight: 454.25
Elemental Analysis: C, 47.59; H, 3.33; Br, 17.59; F, 12.55; N, 15.42; O, 3.52
The following data is based on the product molecular weight 454.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |