BG-1 | CAS$# | PaX2 inhibitor

MedKoo Cat#: 208126 | Name: BG-1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BG-1 is a novel PaX2 inhibitor.

Chemical Structure

BG-1

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 208126

Name: BG-1

CAS#: N/A

Chemical Formula: C19H24N6

Exact Mass: 336.2062

Molecular Weight: 336.44

Elemental Analysis: C, 67.83; H, 7.19; N, 24.98

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

BG-1; BG 1; BG1

IUPAC/Chemical Name

7-(4-(2,5-dimethylphenyl)piperazin-1-yl)-5,6-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine

InChi Key

JFHKCLLXEVVWNH-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H24N6/c1-13-5-6-14(2)17(11-13)23-7-9-24(10-8-23)18-15(3)16(4)22-19-20-12-21-25(18)19/h5-6,11-12H,7-10H2,1-4H3

SMILES Code

CC1=NC2=NC=NN2C(N3CCN(C4=CC(C)=CC=C4C)CC3)=C1C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 336.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: The role of fenhexamid on the proliferation of ovarian cancer BG-1 cells [Retraction]. Int J Clin Exp Pathol. 2020 Mar 1;13(3):634. PMID: 32269705; PMCID: PMC7137021. 2: Wu GJ. Enforced Expression of METCAM/MUC18 Decreases In Vitro Motility and Invasiveness and Tumorigenesis and In Vivo Tumorigenesis of Human Ovarian Cancer BG-1 Cells. Adv Exp Med Biol. 2021;1330:125-137. doi: 10.1007/978-3-030-73359-9_8. PMID: 34339034. 3: Baldwin WS, Curtis SW, Cauthen CA, Risinger JI, Korach KS, Barrett JC. BG-1 ovarian cell line: an alternative model for examining estrogen-dependent growth in vitro. In Vitro Cell Dev Biol Anim. 1998 Sep;34(8):649-54. doi: 10.1007/s11626-996-0015-9. PMID: 9769151. 4: Fei A, Fu H, Jiang H, Wei L, Zhang H, Fei A, Zhang Y, Zou T, Gao S, Li L, Jiang H, Zhou M, Xing H, Huang Y. The role of fenhexamid on the proliferation of ovarian cancer BG-1 cells. Int J Clin Exp Pathol. 2018 Apr 1;11(4):2025-2031. Retraction in: Int J Clin Exp Pathol. 2020 Mar 01;13(3):634. PMID: 31938309; PMCID: PMC6958182. 5: Park MA, Hwang KA, Lee HR, Yi BR, Jeung EB, Choi KC. Benzophenone-1 stimulated the growth of BG-1 ovarian cancer cells by cell cycle regulation via an estrogen receptor alpha-mediated signaling pathway in cellular and xenograft mouse models. Toxicology. 2013 Mar 8;305:41-8. doi: 10.1016/j.tox.2012.12.021. Epub 2013 Jan 14. PMID: 23328252. 6: Li Y, Arao Y, Hall JM, Burkett S, Liu L, Gerrish K, Cavailles V, Korach KS. Research Resource: STR DNA profile and gene expression comparisons of human BG-1 cells and a BG-1/MCF-7 clonal variant. Mol Endocrinol. 2014 Dec;28(12):2072-81. doi: 10.1210/me.2014-1229. PMID: 25321415; PMCID: PMC4250366. 7: Hwang KA, Park MA, Kang NH, Yi BR, Hyun SH, Jeung EB, Choi KC. Anticancer effect of genistein on BG-1 ovarian cancer growth induced by 17 β-estradiol or bisphenol A via the suppression of the crosstalk between estrogen receptor α and insulin-like growth factor-1 receptor signaling pathways. Toxicol Appl Pharmacol. 2013 Nov 1;272(3):637-46. doi: 10.1016/j.taap.2013.07.027. Epub 2013 Aug 8. PMID: 23933164. 8: Kang NH, Hwang KA, Lee HR, Choi DW, Choi KC. Resveratrol regulates the cell viability promoted by 17β-estradiol or bisphenol A via down-regulation of the cross-talk between estrogen receptor α and insulin growth factor-1 receptor in BG-1 ovarian cancer cells. Food Chem Toxicol. 2013 Sep;59:373-9. doi: 10.1016/j.fct.2013.06.029. Epub 2013 Jun 27. PMID: 23810794. 9: Kim CW, Go RE, Choi KC. Treatment of BG-1 Ovarian Cancer Cells Expressing Estrogen Receptors with Lambda-cyhalothrin and Cypermethrin Caused a Partial Estrogenicity Via an Estrogen Receptor-dependent Pathway. Toxicol Res. 2015 Dec;31(4):331-7. doi: 10.5487/TR.2015.31.4.331. PMID: 26877835; PMCID: PMC4751442. 10: Davanos N, Panos G, Gogos CA, Mouzaki A. HIV-1 subtype characteristics of infected persons living in southwestern Greece. HIV AIDS (Auckl). 2015 Dec 11;7:277-83. doi: 10.2147/HIV.S90755. PMID: 26715861; PMCID: PMC4686321. 11: Shin S, Go RE, Kim CW, Hwang KA, Nam KH, Choi KC. Effect of benzophenone-1 and octylphenol on the regulation of epithelial-mesenchymal transition via an estrogen receptor-dependent pathway in estrogen receptor expressing ovarian cancer cells. Food Chem Toxicol. 2016 Jul;93:58-65. doi: 10.1016/j.fct.2016.04.026. Epub 2016 May 1. PMID: 27145024. 12: Cartee L, Kucera GL, Willingham MC. Induction of apoptosis by gemcitabine in BG-1 human ovarian cancer cells compared with induction by staurosporine, paclitaxel and cisplatin. Apoptosis. 1998 Dec;3(6):439-49. doi: 10.1023/a:1009614703977. PMID: 14646477. 13: Kang NH, Hwang KA, Kim TH, Hyun SH, Jeung EB, Choi KC. Induced growth of BG-1 ovarian cancer cells by 17β-estradiol or various endocrine disrupting chemicals was reversed by resveratrol via downregulation of cell cycle progression. Mol Med Rep. 2012 Jul;6(1):151-6. doi: 10.3892/mmr.2012.887. Epub 2012 Apr 23. PMID: 22552626. 14: Coutouné N, Mulato AT, Riaño-Pachón DM, Oliveira JV. Draft Genome Sequence of Saccharomyces cerevisiae Barra Grande (BG-1), a Brazilian Industrial Bioethanol-Producing Strain. Genome Announc. 2017 Mar 30;5(13):e00111-17. doi: 10.1128/genomeA.00111-17. PMID: 28360170; PMCID: PMC5374244. 15: Li Y, You M, Liu H, Liu X. Comparison of distribution and physicochemical properties of β-glucan extracted from different fractions of highland barley grains. Int J Biol Macromol. 2021 Oct 31;189:91-99. doi: 10.1016/j.ijbiomac.2021.08.094. Epub 2021 Aug 18. PMID: 34418418. 16: Park MA, Hwang KA, Lee HR, Yi BR, Jeung EB, Choi KC. Cell growth of BG-1 ovarian cancer cells is promoted by di-n-butyl phthalate and hexabromocyclododecane via upregulation of the cyclin D and cyclin-dependent kinase-4 genes. Mol Med Rep. 2012 Mar;5(3):761-6. doi: 10.3892/mmr.2011.712. Epub 2011 Dec 15. PMID: 22179484. 17: Cartee L, Kucera GL. Gemcitabine induces programmed cell death and activates protein kinase C in BG-1 human ovarian cancer cells. Cancer Chemother Pharmacol. 1998;41(5):403-12. doi: 10.1007/s002800050758. PMID: 9523737. 18: Hwang KA, Kang NH, Yi BR, Lee HR, Park MA, Choi KC. Genistein, a soy phytoestrogen, prevents the growth of BG-1 ovarian cancer cells induced by 17β-estradiol or bisphenol A via the inhibition of cell cycle progression. Int J Oncol. 2013 Feb;42(2):733-40. doi: 10.3892/ijo.2012.1719. Epub 2012 Nov 29. PMID: 23229410. 19: Vasco ACCM, Brinkley-Bissinger KJ, Bobel JM, Dubeux JCB, Warren LK, Wickens CL. Digestibility and nitrogen and water balance in horses fed rhizoma peanut hay. J Anim Sci. 2021 Nov 1;99(11):skab284. doi: 10.1093/jas/skab284. PMID: 34634110; PMCID: PMC8763232. 20: Kim J, Kim HJ, Chang SW, Oh S, Kim SY, Choi KK, Kim DS, Jang JH. Effect of bioactive glass addition on the physical properties of mineral trioxide aggregate. Biomater Res. 2021 Nov 24;25(1):39. doi: 10.1186/s40824-021-00238-2. PMID: 34819173; PMCID: PMC8611879.