FR167344 | CAS#215258-13-2 | B2 receptor antagonist

MedKoo Cat#: 531787 | Name: FR167344

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FR167344 is a novel, potent and orally active nonpeptide bradykinin B2 receptor antagonist used in vivo models of inflammation.

Chemical Structure

FR167344

CAS#215258-13-2

Theoretical Analysis

MedKoo Cat#: 531787

Name: FR167344

CAS#: 215258-13-2

Chemical Formula: C30H28BrCl2N5O4

Exact Mass: 671.0702

Molecular Weight: 673.39

Elemental Analysis: C, 53.51; H, 4.19; Br, 11.87; Cl, 10.53; N, 10.40; O, 9.50

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

FR167344; FR-167344; FR 167344.

IUPAC/Chemical Name

4-[(E)-3-[[2-[[3-[(3-bromo-2-methylimidazo[1,2-a]pyridin-8-yl)oxymethyl]-2,4-dichlorophenyl]-methylamino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N,N-dimethylbenzamide

InChi Key

NDOBHDUXUJNXHX-NTEUORMPSA-N

InChi Code

InChI=1S/C30H28BrCl2N5O4/c1-18-28(31)38-15-5-6-24(29(38)35-18)42-17-21-22(32)12-13-23(27(21)33)37(4)26(40)16-34-25(39)14-9-19-7-10-20(11-8-19)30(41)36(2)3/h5-15H,16-17H2,1-4H3,(H,34,39)/b14-9+

SMILES Code

O=C(N(C)C)C1=CC=C(/C=C/C(NCC(N(C2=CC=C(Cl)C(COC3=CC=CN4C3=NC(C)=C4Br)=C2Cl)C)=O)=O)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 673.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Asano M, Sawai H, Hatori C, Inamura N, Fujiwara T, Nakahara K. Effects of a nonpeptide bradykinin B2 receptor antagonist, FR167344, on guinea-pig tracheal smooth muscle bradykinin receptors. Can J Physiol Pharmacol. 1998 Oct-Nov;76(10-11):1051-5. PubMed PMID: 10100888. 2: Asano M, Hatori C, Inamura N, Sawai H, Hirosumi J, Fujiwara T, Nakahara K. Effects of a nonpeptide bradykinin B2 receptor antagonist, FR167344, on different in vivo animal models of inflammation. Br J Pharmacol. 1997 Dec;122(7):1436-40. PubMed PMID: 9421292; PubMed Central PMCID: PMC1565090. 3: Inamura N, Asano M, Hatori C, Sawai H, Hirosumi J, Fujiwara T, Kayakiri H, Satoh S, Abe Y, Inoue T, Sawada Y, Oku T, Nakahara K. Pharmacological characterization of a novel, orally active, nonpeptide bradykinin B2 receptor antagonist, FR167344. Eur J Pharmacol. 1997 Aug 20;333(1):79-86. PubMed PMID: 9311664. 4: Aramori I, Zenkoh J, Morikawa N, O'Donnell N, Asano M, Nakamura K, Iwami M, Kojo H, Notsu Y. Novel subtype-selective nonpeptide bradykinin receptor antagonists FR167344 and FR173657. Mol Pharmacol. 1997 Feb;51(2):171-6. PubMed PMID: 9203620.