FR20 | CAS#570373-45-4 | mPGES 1 inhibitor

MedKoo Cat#: 558413 | Name: FR20

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FR20 is an inhibitor of human microsomal prostaglandin synthase 1 (mPGES 1).

Chemical Structure

FR20

CAS#570373-45-4

Theoretical Analysis

MedKoo Cat#: 558413

Name: FR20

CAS#: 570373-45-4

Chemical Formula: C31H25Cl2N3O2

Exact Mass: 541.1300

Molecular Weight: 542.46

Elemental Analysis: C, 68.64; H, 4.65; Cl, 13.07; N, 7.75; O, 5.90

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

FR20; FR-20; FR 20;

IUPAC/Chemical Name

2-Chloro-N-[3-[(3'-chloro[1,1'-biphenyl]-4-yl)methyl]-3,4-dihydro-4-oxo-2-propyl-6-quinazolinyl]-benzamide

InChi Key

FFCSFKNIGKSNHT-UHFFFAOYSA-N

InChi Code

InChI=1S/C31H25Cl2N3O2/c1-2-6-29-35-28-16-15-24(34-30(37)25-9-3-4-10-27(25)33)18-26(28)31(38)36(29)19-20-11-13-21(14-12-20)22-7-5-8-23(32)17-22/h3-5,7-18H,2,6,19H2,1H3,(H,34,37)

SMILES Code

O=C(NC1=CC2=C(N=C(CCC)N(CC3=CC=C(C4=CC=CC(Cl)=C4)C=C3)C2=O)C=C1)C5=CC=CC=C5Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 542.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: da Silva GP, Fernandes DC, Vigliano MV, da Fonseca EN, Santos SV, Marques PR, Justo MD, Sabino KC, Coelho MG. Flavonoid-enriched fraction from Echinodorus macrophyllus aqueous extract exhibits high in-vitro and in-vivo anti-inflammatory activity. J Pharm Pharmacol. 2016 Dec;68(12):1584-1596. doi: 10.1111/jphp.12620. Epub 2016 Oct 10. PubMed PMID: 27726146. 2: Dienel GA, Cruz NF, Ball K, Popp D, Gokden M, Baron S, Wright D, Wenger GR. Behavioral training increases local astrocytic metabolic activity but does not alter outcome of mild transient ischemia. Brain Res. 2003 Jan 31;961(2):201-12. PubMed PMID: 12531487. 3: Wilson RD, Islam MS. Fructose-fed streptozotocin-injected rat: an alternative model for type 2 diabetes. Pharmacol Rep. 2012;64(1):129-39. PubMed PMID: 22580529. 4: Randall PA, Nunes EJ, Janniere SL, Stopper CM, Farrar AM, Sager TN, Baqi Y, Hockemeyer J, Müller CE, Salamone JD. Stimulant effects of adenosine antagonists on operant behavior: differential actions of selective A2A and A1 antagonists. Psychopharmacology (Berl). 2011 Jul;216(2):173-86. doi: 10.1007/s00213-011-2198-3. Epub 2011 Feb 24. PubMed PMID: 21347642; PubMed Central PMCID: PMC3522121. 5: Umezu T, Shibata Y. Different behavioral effect dose-response profiles in mice exposed to two-carbon chlorinated hydrocarbons: influence of structural and physical properties. Toxicol Appl Pharmacol. 2014 Sep 1;279(2):103-12. doi: 10.1016/j.taap.2014.05.012. Epub 2014 Jun 6. PubMed PMID: 24910396. 6: Genovese RF, Lu XC. Effects of MK-801 stereoisomers on schedule-controlled behavior in rats. Psychopharmacology (Berl). 1991;105(4):477-80. PubMed PMID: 1771215. 7: Moerschbaecher JM, Mastropaolo J, Winsauer PJ, Thompson DM. Effects of opioids on accuracy of a fixed-ratio discrimination in monkeys and rats. J Pharmacol Exp Ther. 1984 Sep;230(3):541-9. PubMed PMID: 6381692. 8: Colombo M, Cottle A, Frost N. Degree of representation of the matching concept in pigeons (Columba livia). J Comp Psychol. 2003 Sep;117(3):246-56. PubMed PMID: 14498800. 9: Hulin MW, Lawrence MN, Amato RJ, Weed PF, Winsauer PJ. Comparison of dehydroepiandrosterone (DHEA) and pregnanolone with existing pharmacotherapies for alcohol abuse on ethanol- and food-maintained responding in male rats. Alcohol. 2015 Mar;49(2):127-38. doi: 10.1016/j.alcohol.2014.07.024. Epub 2015 Jan 6. PubMed PMID: 25620274; PubMed Central PMCID: PMC4514518. 10: Shannon HE, Guzman F, Cook JM. beta-Carboline-3-carboxylate-t-butyl ester: a selective BZ1 benzodiazepine receptor antagonist. Life Sci. 1984 Nov 26;35(22):2227-36. PubMed PMID: 6094935. 11: Lucki I, Kucharik RF. Increased sensitivity to benzodiazepine antagonists in rats following chronic treatment with a low dose of diazepam. Psychopharmacology (Berl). 1990;102(3):350-6. PubMed PMID: 1979180. 12: Clement TS, Feltus JR, Kaiser DH, Zentall TR. "Work ethic" in pigeons: reward value is directly related to the effort or time required to obtain the reward. Psychon Bull Rev. 2000 Mar;7(1):100-6. PubMed PMID: 10780022. 13: Stein EA. Ventral tegmental self-stimulation selectively induces opioid peptide release in rat CNS. Synapse. 1993 Jan;13(1):63-73. PubMed PMID: 8427014. 14: Norwood AP, Al-Chaer ED, Fantegrossi WE. Predisposing effects of neonatal visceral pain on abuse-related effects of morphine in adult male Sprague Dawley rats. Psychopharmacology (Berl). 2014 Nov;231(22):4281-9. doi: 10.1007/s00213-014-3574-6. Epub 2014 Apr 23. PubMed PMID: 24756764; PubMed Central PMCID: PMC5384261. 15: Ostlund SB, Kosheleff AR, Maidment NT. Relative response cost determines the sensitivity of instrumental reward seeking to dopamine receptor blockade. Neuropsychopharmacology. 2012 Nov;37(12):2653-60. doi: 10.1038/npp.2012.129. Epub 2012 Jul 18. PubMed PMID: 22805602; PubMed Central PMCID: PMC3473331. 16: Chang YH, Liao RM, Lan CH, Shen YL. Operant performance following tail-pinch in the rat: effects of d-amphetamine. Chin J Physiol. 2000 Sep 30;43(3):105-11. PubMed PMID: 11132086. 17: Rörsch F, Buscató E, Deckmann K, Schneider G, Schubert-Zsilavecz M, Geisslinger G, Proschak E, Grösch S. Structure-activity relationship of nonacidic quinazolinone inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1). J Med Chem. 2012 Apr 26;55(8):3792-803. doi: 10.1021/jm201687d. Epub 2012 Apr 11. PubMed PMID: 22449023. 18: Furuya I, Watanabe S. [Discriminative stimulus properties of ephedra herb (Ephedra sinica) in rats]. Yakubutsu Seishin Kodo. 1993 Feb;13(1):33-8. Japanese. PubMed PMID: 8317176. 19: Christoph GR, Kelly DP, Krivanek N. Acute inhalation exposure to cyclohexane and schedule-controlled operant performance in rats: comparison to d-amphetamine and chlorpromazine. Drug Chem Toxicol. 2000 Nov;23(4):539-53. PubMed PMID: 11071394. 20: Gauthier CA, Gerak LR, Bagley JR, Brockunier LL, France CP. The rate-decreasing effects of fentanyl derivatives in pigeons before, during and after chronic morphine treatment. Psychopharmacology (Berl). 1998 May;137(1):67-73. PubMed PMID: 9631958.