MedKoo Cat#: 513678 | Name: CGP 62349

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CGP 62349 is a GABAB receptor antagonist.

Chemical Structure

CGP 62349
CGP 62349
CAS#187608-26-0

Theoretical Analysis

MedKoo Cat#: 513678

Name: CGP 62349

CAS#: 187608-26-0

Chemical Formula: C21H28NO6P

Exact Mass: 421.1654

Molecular Weight: 421.43

Elemental Analysis: C, 59.85; H, 6.70; N, 3.32; O, 22.78; P, 7.35

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CGP 62349; CGP-62349; CGP62349.
IUPAC/Chemical Name
3-[(1R)-1-[[(2S)-2-hydroxy-3-[hydroxy-[(4-methoxyphenyl)methyl]phosphoryl]propyl]-methylamino]ethyl]benzoic acid
InChi Key
AKUSEWDIEMJQBM-BEFAXECRSA-N
InChi Code
InChI=1S/C21H28NO6P/c1-15(17-5-4-6-18(11-17)21(24)25)22(2)12-19(23)14-29(26,27)13-16-7-9-20(28-3)10-8-16/h4-11,15,19,23H,12-14H2,1-3H3,(H,24,25)(H,26,27)/t15-,19+/m1/s1
SMILES Code
O=C(O)C1=CC=CC([C@H](N(C[C@H](O)CP(CC2=CC=C(OC)C=C2)(O)=O)C)C)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 421.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Keir MJ, Barakat MJ, Dev KK, Bittiger H, Bettler B, Henley JM. Characterisation and partial purification of the GABA(B) receptor from the rat cerebellum using the novel antagonist [3H]CGP 62349. Brain Res Mol Brain Res. 1999 Aug 25;71(2):279-89. PubMed PMID: 10521582. 2: Ambardekar AV, Ilinsky IA, Forestl W, Bowery NG, Kultas-Ilinsky K. Distribution and properties of GABA(B) antagonist [3H]CGP 62349 binding in the rhesus monkey thalamus and basal ganglia and the influence of lesions in the reticular thalamic nucleus. Neuroscience. 1999;93(4):1339-47. PubMed PMID: 10501458.