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MedKoo Cat#: 597856 | Name: CL 242817

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CL 242817 is an angiotensin converting enzyme (ACE) inhibitor.

Chemical Structure

CL 242817
CL 242817
CAS#86709-48-0

Theoretical Analysis

MedKoo Cat#: 597856

Name: CL 242817

CAS#: 86709-48-0

Chemical Formula: C18H21NO5S

Exact Mass: 363.1140

Molecular Weight: 363.42

Elemental Analysis: C, 59.49; H, 5.82; N, 3.85; O, 22.01; S, 8.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CL 242817; CL-242817; CL242817;
IUPAC/Chemical Name
((2R,3S)-3-(acetylthio)-2-methyl-4-oxo-4-phenylbutanoyl)-L-proline
InChi Key
FLRNAFWKDUMBPC-PJODQICGSA-N
InChi Code
InChI=1S/C18H21NO5S/c1-11(17(22)19-10-6-9-14(19)18(23)24)16(25-12(2)20)15(21)13-7-4-3-5-8-13/h3-5,7-8,11,14,16H,6,9-10H2,1-2H3,(H,23,24)/t11-,14-,16-/m0/s1
SMILES Code
O=C(O)[C@H]1N(C([C@@H](C)[C@H](SC(C)=O)C(C2=CC=CC=C2)=O)=O)CCC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 363.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ward WF, Molteni A, Ts'ao CH. Radiation-induced endothelial dysfunction and fibrosis in rat lung: modification by the angiotensin converting enzyme inhibitor CL242817. Radiat Res. 1989 Feb;117(2):342-50. PubMed PMID: 2922477. 2: Ward WF, Molteni A, Ts'ao CH, Kim YT, Hinz JM. Radiation pneumotoxicity in rats: modification by inhibitors of angiotensin converting enzyme. Int J Radiat Oncol Biol Phys. 1992;22(3):623-5. PubMed PMID: 1735701. 3: Catravas JD, Ryan JW, Chung AY, Quinn NE, Anthony BL. Inhibition of endothelial-bound angiotensin converting enzyme, in vivo. Br J Pharmacol. 1990 Sep;101(1):121-7. PubMed PMID: 2282454; PubMed Central PMCID: PMC1917633. 4: Molteni A, Ward WF, Ts'ao CH, Solliday NH. Monocrotaline-induced cardiopulmonary damage in rats: amelioration by the angiotensin-converting enzyme inhibitor CL242817. Proc Soc Exp Biol Med. 1986 Sep;182(4):483-93. PubMed PMID: 3016747.