CGP 64213 | CAS# 200402-50-2 | GABAb receptor agonist

MedKoo Cat#: 513679 | Name: CGP 64213

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CGP 64213 is a GABAb receptor agonist.

Chemical Structure

CGP 64213

CAS# 200402-50-2

Theoretical Analysis

MedKoo Cat#: 513679

Name: CGP 64213

CAS#: 200402-50-2

Chemical Formula: C26H36IN2O7P

Exact Mass: 646.1305

Molecular Weight: 646.46

Elemental Analysis: C, 48.31; H, 5.61; I, 19.63; N, 4.33; O, 17.32; P, 4.79

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

CGP 64213; CGP-64213; CGP64213.

IUPAC/Chemical Name

3-[(1R)-1-[[(2S)-2-hydroxy-3-[hydroxy-[5-[3-(4-hydroxy-3-iodophenyl)propanoylamino]pentyl]phosphoryl]propyl]amino]ethyl]benzoic acid

InChi Key

RLYLJDJFHZHCTR-GCJKJVERSA-N

InChi Code

InChI=1S/C26H36IN2O7P/c1-18(20-6-5-7-21(15-20)26(33)34)29-16-22(30)17-37(35,36)13-4-2-3-12-28-25(32)11-9-19-8-10-24(31)23(27)14-19/h5-8,10,14-15,18,22,29-31H,2-4,9,11-13,16-17H2,1H3,(H,28,32)(H,33,34)(H,35,36)/t18-,22+/m1/s1

SMILES Code

O=C(O)C1=CC=CC([C@H](NC[C@H](O)CP(CCCCCNC(CCC2=CC=C(O)C(I)=C2)=O)(O)=O)C)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 646.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

2: Duthey B, Caudron S, Perroy J, Bettler B, Fagni L, Pin JP, Prézeau L. A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor. J Biol Chem. 2002 Feb 1;277(5):3236-41. PubMed PMID: 11711539; PubMed Central PMCID: PMC2566549. 3: Calon F, Lavertu N, Lemieux AM, Morissette M, Goulet M, Grondin R, Blanchet PJ, Bédard PJ, Di Paolo T. Effect of MPTP-induced denervation on basal ganglia GABA(B) receptors: correlation with dopamine concentrations and dopamine transporter. Synapse. 2001 Jun 1;40(3):225-34. PubMed PMID: 11304760. 4: Calon F, Morissette M, Goulet M, Grondin R, Blanchet PJ, Bédard PJ, Di Paolo T. 125I-CGP 64213 binding to GABA(B) receptors in the brain of monkeys: effect of MPTP and dopaminomimetic treatments. Exp Neurol. 2000 May;163(1):191-9. PubMed PMID: 10785458. 5: Froestl W, Bettler B, Bittiger H, Heid J, Kaupmann K, Mickel SJ, Strub D. Ligands for the isolation of GABA(B) receptors [corrected] . Neuropharmacology. 1999 Nov;38(11):1641-6. Review. Erratum in: Neuropharmacology 1999 Dec;38(12):1921. PubMed PMID: 10587079. 6: Bowery NG. Metabotropic GABA(B) receptors cloned at last. Trends Pharmacol Sci. 1997 Apr;18(4):103. Review. PubMed PMID: 9149536. 7: Kaupmann K, Huggel K, Heid J, Flor PJ, Bischoff S, Mickel SJ, McMaster G, Angst C, Bittiger H, Froestl W, Bettler B. Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature. 1997 Mar 20;386(6622):239-46. PubMed PMID: 9069281. 8: Bowery NG, Brown DA. The cloning of GABA(B) receptors. Nature. 1997 Mar 20;386(6622):223-4. PubMed PMID: 9069276.