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MedKoo Cat#: 531657 | Name: CCG-100602

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells with an IC50 value of 9.8 µM.

Chemical Structure

CCG-100602
CCG-100602
CAS#1207113-88-9

Theoretical Analysis

MedKoo Cat#: 531657

Name: CCG-100602

CAS#: 1207113-88-9

Chemical Formula: C21H17ClF6N2O2

Exact Mass: 478.0883

Molecular Weight: 478.82

Elemental Analysis: C, 52.68; H, 3.58; Cl, 7.40; F, 23.81; N, 5.85; O, 6.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CCG-100602; CCG 100602; CCG100602.
IUPAC/Chemical Name
[3,5-bis(trifluoromethyl)benzoyl]-N-(4-chlorophenyl)piperidine-3-carboxamide
InChi Key
KIGLPXRFIWBAEQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H17ClF6N2O2/c22-16-3-5-17(6-4-16)30(18(31)12-2-1-7-29-11-12)19(32)13-8-14(20(23,24)25)10-15(9-13)21(26,27)28/h3-6,8-10,12,29H,1-2,7,11H2
SMILES Code
O=C(C1CNCCC1)N(C(C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=O)C3=CC=C(Cl)C=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 478.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Watanabe B, Minami S, Ishida H, Yoshioka R, Nakagawa Y, Morita T, Hayashi K. Stereospecific Inhibitory Effects of CCG-1423 on the Cellular Events Mediated by Myocardin-Related Transcription Factor A. PLoS One. 2015 Aug 21;10(8):e0136242. doi: 10.1371/journal.pone.0136242. PubMed PMID: 26295164; PubMed Central PMCID: PMC4546662. 2: Johnson LA, Rodansky ES, Haak AJ, Larsen SD, Neubig RR, Higgins PD. Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-β-induced fibrogenesis in human colonic myofibroblasts. Inflamm Bowel Dis. 2014 Jan;20(1):154-65. doi: 10.1097/01.MIB.0000437615.98881.31. PubMed PMID: 24280883; PubMed Central PMCID: PMC4893808.