MedKoo Cat#: 563085 | Name: Nocardicin G

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nocardicin G is the universal precursor of the nocardicins.

Chemical Structure

Nocardicin G
Nocardicin G
CAS#65309-11-7

Theoretical Analysis

MedKoo Cat#: 563085

Name: Nocardicin G

CAS#: 65309-11-7

Chemical Formula: C19H19N3O6

Exact Mass: 385.1274

Molecular Weight: 385.37

Elemental Analysis: C, 59.22; H, 4.97; N, 10.90; O, 24.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Nocardicin G; Nocardicin-G;
IUPAC/Chemical Name
(2R)-2-[(3S)-3-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-2-oxoazetidin-1-yl]-2-(4-hydroxyphenyl)acetic acid
InChi Key
SAVAPYNOQXYBJS-ARFHVFGLSA-N
InChi Code
InChI=1S/C19H19N3O6/c20-15(10-1-5-12(23)6-2-10)17(25)21-14-9-22(18(14)26)16(19(27)28)11-3-7-13(24)8-4-11/h1-8,14-16,23-24H,9,20H2,(H,21,25)(H,27,28)/t14-,15+,16+/m0/s1
SMILES Code
O=C(O)[C@H](N1C([C@@H](NC([C@H](N)C2=CC=C(O)C=C2)=O)C1)=O)C3=CC=C(O)C=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 385.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gaudelli NM, Townsend CA. Epimerization and substrate gating by a TE domain in β-lactam antibiotic biosynthesis. Nat Chem Biol. 2014 Apr;10(4):251-8. doi: 10.1038/nchembio.1456. Epub 2014 Feb 16. PubMed PMID: 24531841; PubMed Central PMCID: PMC3961552. 2: Reeve AM, Breazeale SD, Townsend CA. Purification, characterization, and cloning of an S-adenosylmethionine-dependent 3-amino-3-carboxypropyltransferase in nocardicin biosynthesis. J Biol Chem. 1998 Nov 13;273(46):30695-703. PubMed PMID: 9804844. 3: Metz R, Henning S, Hammes WP. LD-carboxypeptidase activity in Escherichia coli. II. Isolation, purification and characterization of the enzyme from E. coli K 12. Arch Microbiol. 1986 Mar;144(2):181-6. PubMed PMID: 3521530. 4: Oka T, Hashizume K, Fujita H. Inhibition of peptidoglycan transpeptidase by beta-lactam antibiotics: structure-activity relationships. J Antibiot (Tokyo). 1980 Nov;33(11):1357-62. PubMed PMID: 6788738. 5: Horikawa S, Ogawara H. Penicillin-binding proteins in Bacillus subtilis. The effects on penicillin-binding proteins and the antibacterial activities of beta-lactams. J Antibiot (Tokyo). 1980 Jun;33(6):614-9. PubMed PMID: 6774958. 6: Pratt RF, Anderson EG, Odeh I. Certain monocyclic beta-lactams are beta-lactamase substrates: nocardicin A and desthiobenzylpenicillin. Biochem Biophys Res Commun. 1980 Apr 29;93(4):1266-73. PubMed PMID: 6772177.