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MedKoo Cat#: 414452 | Name: Nolotil

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nolotil is a painkiller, spasm reliever, and fever reliever that also has anti-inflammatory effects. It is most commonly given by mouth or by injection.

Chemical Structure

Nolotil
Nolotil
CAS#54017-59-3

Theoretical Analysis

MedKoo Cat#: 414452

Name: Nolotil

CAS#: 54017-59-3

Chemical Formula: C26H32MgN6O8S2

Exact Mass: 644.1573

Molecular Weight: 645.00

Elemental Analysis: C, 48.42; H, 5.00; Mg, 3.77; N, 13.03; O, 19.84; S, 9.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Nolotil; Metamizole
IUPAC/Chemical Name
magnesium ((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl)amino)methanesulfonate
InChi Key
NHMUJYOBLYTIKO-UHFFFAOYSA-L
InChi Code
InChI=1S/2C13H17N3O4S.Mg/c2*1-10-12(14(2)9-21(18,19)20)13(17)16(15(10)3)11-7-5-4-6-8-11;/h2*4-8H,9H2,1-3H3,(H,18,19,20);/q;;+2/p-2
SMILES Code
CN(C1=C(N(N(c2ccccc2)C1=O)C)C)CS(=O)(O[Mg]OS(=O)(CN(C3=C(N(N(c4ccccc4)C3=O)C)C)C)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 645.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Dalmau J, Serra-Baldrich E, Roé E, Peramiquel L, Alomar A. Use of patch test in fixed drug eruption due to metamizole (Nolotil). Contact Dermatitis. 2006 Feb;54(2):127-8. doi: 10.1111/j.0105-1873.2006.0560i.x. PMID: 16487292. 2: Ortiz-Gómez JR, Perepérez-Candel M, Vázquez-Torres JM, Rodriguez-Del Río JM, Torrón-Abad B, Fornet-Ruiz I, Palacio-Abizanda FJ. Postoperative analgesia for elective total knee arthroplasty under subarachnoid anesthesia with opioids: comparison between epidural, femoral block and adductor canal block techniques (with and without perineural adjuvants). A prospective, randomized, clinical trial. Minerva Anestesiol. 2017 Jan;83(1):50-58. doi: 10.23736/S0375-9393.16.11646-3. Epub 2016 Oct 28. PMID: 27792212. 3: Hopen G, Ly B, Moen T. Agranulocytose etter bruk av utenlandske "hodepinetabletter" (Optalidon og Nolotil) [Agranulocytosis caused by foreign analgesics (Optalidon and Nolotil)]. Tidsskr Nor Laegeforen. 1979 May 10;99(13):635. Norwegian. PMID: 451964. 4: Criado A, Domínguez E, García Cubero A, López A, Navarro E. Shock anafiláctico y parada cardíaca por administración endovenosa de nolotil [Anaphylactic shock and cardiac arrest by intravenous administration of nolotil]. Rev Esp Anestesiol Reanim. 1979 Nov;26(6):600-3. Spanish. PMID: 547318. 5: Marín-Bertolín S, De Andrés J, González-Martínez R, Valia Vera JC, Amorrortu- Velayos J. A controlled, randomized, double-blind study of ketorolac for postoperative analgesia after plastic surgery. Ann Plast Surg. 1997 May;38(5):478-84. PMID: 9160129. 6: Ibáñez L, Vidal X, Ballarín E, Laporte JR. Population-based drug-induced agranulocytosis. Arch Intern Med. 2005 Apr 25;165(8):869-74. doi: 10.1001/archinte.165.8.869. PMID: 15851637. 7: Bellens JJ. Livstruende forgiftning med udenlandsk håndkøbsmedicin (Nolotil) [Life endangering poisoning with a foreign patent medicine (Nolotil)]. Ugeskr Laeger. 1976 Nov 29;138(49):3123-4. Danish. PMID: 996950. 8: Martin-Garcia C, Martinez-Borque N, Martinez-Bohigas D, Torrecillas-Toro M, Palomeque-Rodrìguez MT. Delayed reaction urticaria due to trimebutine. Allergy. 2004 Jul;59(7):789-90. doi: 10.1111/j.1398-9995.2004.00443.x. PMID: 15180771. 9: Calvo Vecino JM, San Norberto L, Abad Gurumeta A, Velasco Villanueva D, Velásquez Muñoz MF, Pico Brezmes S, Pérez Gallardo A. Levobupivacaína versus bupivacaína racémica para anestesia/analgesia epidural toráicica y lumbar alta en niños [Levobupivacaine versus racemic bupivacaine for thoracic and upper lumbar epidural anesthesia-analgesia in children]. Rev Esp Anestesiol Reanim. 2007 May;54(5):288-96. Spanish. PMID: 17598719. 10: R Ortiz-Gómez J, Perepérez-Candel M, Pavón-Benito A, Torrón-Abad B, Dorronsoro-Auzmendi M, Martínez-García Ó, Zabaleta-Zúñiga AR, Azcona-Calahorra MA, Fornet-Ruiz I, Ortiz-Domínguez A, Palacio-Abizanda FJ. A randomized clinical trial comparing six techniques of postoperative analgesia for elective total hip arthroplasty under subarachnoid anesthesia with opioids. Minerva Anestesiol. 2021 Jun;87(6):663-674. doi: 10.23736/S0375-9393.21.14957-0. Epub 2021 Feb 16. PMID: 33591141.

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