BMS493 is an inverse agonist of pan-retinoic acid receptors (pan-RARs). BMS493 has been shown to increase nuclear corepressor (NCoR) interaction with RARs. In cellular culture, pretreatment of BMS493 on MEPM cells blocked atRA-induced apoptotic indexes. BMS493 completely inhibited atRA-induced Sub-G1 fraction, DNA fragmentation, and caspase-3 activation.
MedKoo Cat#: 531556
Name: BMS493
CAS#: 215030-90-3
Chemical Formula: C29H24O2
Exact Mass: 404.1776
Molecular Weight: 404.51
Elemental Analysis: C, 86.11; H, 5.98; O, 7.91
The following data is based on the product molecular weight 404.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
