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MedKoo Cat#: 529710 | Name: SUN-1334H (HCl)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SUN-1334H is a histamine H1 receptor antagonist potentially for the treatment of allergic conjunctivitis and allergic rhinitis

Chemical Structure

SUN-1334H (HCl)
SUN-1334H (HCl)
CAS#607736-84-5 (HCl)

Theoretical Analysis

MedKoo Cat#: 529710

Name: SUN-1334H (HCl)

CAS#: 607736-84-5 (HCl)

Chemical Formula: C23H28Cl2F2N2O3

Exact Mass: 0.0000

Molecular Weight: 489.38

Elemental Analysis: C, 56.45; H, 5.77; Cl, 14.49; F, 7.76; N, 5.72; O, 9.81

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
607737-00-8 (free base) 607736-84-5 (HCl)
Synonym
1334H; SUN-1334H; SUN 1334H;
IUPAC/Chemical Name
(E)-2-((4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)but-2-en-1-yl)oxy)acetic acid dihydrochloride
InChi Key
KAQMKGKFTBFMGE-SEPHDYHBSA-N
InChi Code
InChI=1S/C23H26F2N2O3.2ClH/c24-20-7-3-18(4-8-20)23(19-5-9-21(25)10-6-19)27-14-12-26(13-15-27)11-1-2-16-30-17-22(28)29;;/h1-10,23H,11-17H2,(H,28,29);2*1H/b2-1+;;
SMILES Code
O=C(O)COC/C=C/CN1CCN(C(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3)CC1.[H]Cl.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 489.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Mandhane SN, Shah JH, Bahekar PC, Mehetre SV, Pawar CA, Bagad AS, Chidrewar GU, Rao CT, Rajamannar T. Characterization of anti-inflammatory properties and evidence for no sedation liability for the novel antihistamine SUN-1334H. Int Arch Allergy Immunol. 2010;151(1):56-69. doi: 10.1159/000232571. PubMed PMID: 19672097. 2: Mandhane SN, Ayer UB, Midha AS, Rao CT, Rajamannar T. Preclinical efficacy and safety pharmacology of SUN-1334H, a potent orally active antihistamine agent. Drugs R D. 2008;9(2):93-112. PubMed PMID: 18298128.

View History

SUN-55786

SUN-55786

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