Tafetinib | CAS#1032265-57-8 | Vascular Endothelial Growth Factor Receptor Inhibitor | Receptor Tyrosine Kinase Inhibitor

MedKoo Cat#: 527406 | Name: Tafetinib

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tafetinib is a vascular endothelial growth factor receptor (VEGFR) inhibitor for the treatment of solid tumors. Tafeinib is also a multi-targeted receptor tyrosine kinase (RTK) inhibitor.

Chemical Structure

Tafetinib

CAS#1032265-57-8

Theoretical Analysis

MedKoo Cat#: 527406

Name: Tafetinib

CAS#: 1032265-57-8

Chemical Formula: C24H29FN4O2

Exact Mass: 424.2275

Molecular Weight: 424.52

Elemental Analysis: C, 67.90; H, 6.89; F, 4.48; N, 13.20; O, 7.54

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Tafetinib, SIM-010603, SIM010603, SIM 010603

IUPAC/Chemical Name

(Z)-N-(2-(diethylamino)ethyl)-7-(5-fluoro-2-oxoindolin-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide

InChi Key

KGSRYTUWXUESJK-FXBPSFAMSA-N

InChi Code

InChI=1S/C24H29FN4O2/c1-4-29(5-2)12-11-26-23(30)20-14(3)27-22-16(20)7-6-8-17(22)21-18-13-15(25)9-10-19(18)28-24(21)31/h9-10,13,27H,4-8,11-12H2,1-3H3,(H,26,30)(H,28,31)/b21-17-

SMILES Code

CCN(CCNC(C1=C(NC2=C1CCC/C2=C3C(NC4=CC=C(C=C/34)F)=O)C)=O)CC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 424.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Shao F, Zhu T, Tang F, Liu X. Simultaneous quantification of tafetinib (SIM010603), a novel potent inhibitor of receptor tyrosine kinase, and its major metabolite in dog plasma by HPLC-ESI/MS/MS and its application to a pharmacokinetic study. J Pharm Biomed Anal. 2013 Jul-Aug;81-82:50-5. doi: 10.1016/j.jpba.2013.02.041. PubMed PMID: 23624508. 2: Mao Y, Xia Z, Zhang X, Zong Y, Zhu L, Yuan B, Lu G. Evaluation of subchronic toxicity of SIM010603, a potent inhibitor of receptor tyrosine kinase, after 28-day repeated oral administration in SD rats and beagle dogs. Food Chem Toxicol. 2012 May;50(5):1256-70. doi: 10.1016/j.fct.2012.02.007. PubMed PMID: 22343322. 3: Wang D, Tang F, Wang S, Jiang Z, Zhang L. Preclinical anti-angiogenesis and anti-tumor activity of SIM010603, an oral, multi-targets receptor tyrosine kinases inhibitor. Cancer Chemother Pharmacol. 2012 Jan;69(1):173-83. doi: 10.1007/s00280-011-1681-1. PubMed PMID: 21638122.