Synonym
GW-695634; GW 695634; GW695634; GW-5634; GW-5634G; GW5634; GW5634G.
IUPAC/Chemical Name
N-(4-(((4-chloro-2-(3-chloro-5-cyanobenzoyl)phenoxy)acetyl)amino)-3-methylphenyl)sulfonylpropanamide
InChi Key
GAQZNFUDILDDDI-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H21Cl2N3O6S/c1-3-24(32)31-38(35,36)20-5-6-22(15(2)8-20)30-25(33)14-37-23-7-4-18(27)12-21(23)26(34)17-9-16(13-29)10-19(28)11-17/h4-12H,3,14H2,1-2H3,(H,30,33)(H,31,32)
SMILES Code
CCC(NS(=O)(C1=CC=C(NC(COC2=CC=C(Cl)C=C2C(C3=CC(C#N)=CC(Cl)=C3)=O)=O)C(C)=C1)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
574.43
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: De Serres M, Bowers G, Boyle G, Beaumont C, Castellino S, Sigafoos J, Dave M,
Roberts A, Shah V, Olson K, Patel D, Wagner D, Yeager R, Serabjit-Singh C.
Evaluation of a chimeric (uPA+/+)/SCID mouse model with a humanized liver for
prediction of human metabolism. Xenobiotica. 2011 Jun;41(6):464-75. doi:
10.3109/00498254.2011.560295. PubMed PMID: 21370990.
2: de Serres M, Moss L, Sigafoos J, Sefler A, Castellino S, Bowers G,
Serabjit-Singh C. The disposition and metabolism of GW695634: a non-nucleoside
reverse transcriptase inhibitor (NNRTi) for treatment of HIV/AIDS. Xenobiotica.
2010 Jun;40(6):437-45. doi: 10.3109/00498251003770578. PubMed PMID: 20380622.
3: Boone LR. Next-generation HIV-1 non-nucleoside reverse transcriptase
inhibitors. Curr Opin Investig Drugs. 2006 Feb;7(2):128-35. Review. PubMed PMID:
16499282.
