GW-695634 | CAS#457635-65-3 | NNRTI

MedKoo Cat#: 526960 | Name: GW-695634

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GW-695634, also known as GW-5634; GW-5634G, is a non-nucleoside reverse transcriptase inhibitor potentially for the treatment of HIV infection.

Chemical Structure

GW-695634

CAS#457635-65-3

Theoretical Analysis

MedKoo Cat#: 526960

Name: GW-695634

CAS#: 457635-65-3

Chemical Formula: C26H21Cl2N3O6S

Exact Mass: 573.0528

Molecular Weight: 574.43

Elemental Analysis: C, 54.36; H, 3.69; Cl, 12.34; N, 7.32; O, 16.71; S, 5.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

GW-695634; GW 695634; GW695634; GW-5634; GW-5634G; GW5634; GW5634G.

IUPAC/Chemical Name

N-(4-(((4-chloro-2-(3-chloro-5-cyanobenzoyl)phenoxy)acetyl)amino)-3-methylphenyl)sulfonylpropanamide

InChi Key

GAQZNFUDILDDDI-UHFFFAOYSA-N

InChi Code

InChI=1S/C26H21Cl2N3O6S/c1-3-24(32)31-38(35,36)20-5-6-22(15(2)8-20)30-25(33)14-37-23-7-4-18(27)12-21(23)26(34)17-9-16(13-29)10-19(28)11-17/h4-12H,3,14H2,1-2H3,(H,30,33)(H,31,32)

SMILES Code

CCC(NS(=O)(C1=CC=C(NC(COC2=CC=C(Cl)C=C2C(C3=CC(C#N)=CC(Cl)=C3)=O)=O)C(C)=C1)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 574.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: De Serres M, Bowers G, Boyle G, Beaumont C, Castellino S, Sigafoos J, Dave M, Roberts A, Shah V, Olson K, Patel D, Wagner D, Yeager R, Serabjit-Singh C. Evaluation of a chimeric (uPA+/+)/SCID mouse model with a humanized liver for prediction of human metabolism. Xenobiotica. 2011 Jun;41(6):464-75. doi: 10.3109/00498254.2011.560295. PubMed PMID: 21370990. 2: de Serres M, Moss L, Sigafoos J, Sefler A, Castellino S, Bowers G, Serabjit-Singh C. The disposition and metabolism of GW695634: a non-nucleoside reverse transcriptase inhibitor (NNRTi) for treatment of HIV/AIDS. Xenobiotica. 2010 Jun;40(6):437-45. doi: 10.3109/00498251003770578. PubMed PMID: 20380622. 3: Boone LR. Next-generation HIV-1 non-nucleoside reverse transcriptase inhibitors. Curr Opin Investig Drugs. 2006 Feb;7(2):128-35. Review. PubMed PMID: 16499282.