GET-73 | CAS#202402-20-5 | mGlu5 receptor allosteric modulator

MedKoo Cat#: 529809 | Name: GET-73

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GET-73 is a mGlu5 receptor allosteric modulator potentially for the treatment of alcoholism.

Chemical Structure

GET-73

CAS#202402-20-5

Theoretical Analysis

MedKoo Cat#: 529809

Name: GET-73

CAS#: 202402-20-5

Chemical Formula: C13H16F3NO2

Exact Mass: 275.1100

Molecular Weight: 275.27

Elemental Analysis: C, 56.72; H, 5.86; F, 20.71; N, 5.09; O, 11.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

GET73; GET 73; GET73

IUPAC/Chemical Name

4-methoxy-N-(4-(trifluoromethyl)benzyl)butanamide

InChi Key

QLZOWJNFLXSDSH-UHFFFAOYSA-N

InChi Code

InChI=1S/C13H16F3NO2/c1-19-8-2-3-12(18)17-9-10-4-6-11(7-5-10)13(14,15)16/h4-7H,2-3,8-9H2,1H3,(H,17,18)

SMILES Code

O=C(NCC1=CC=C(C(F)(F)F)C=C1)CCCOC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 275.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Tomasini MC, Borelli AC, Beggiato S, Tanganelli S, Loche A, Cacciaglia R, Ferraro L, Antonelli T. GET73 Prevents Ethanol-Induced Neurotoxicity in Primary Cultures of Rat Hippocampal Neurons. Alcohol Alcohol. 2016 Mar;51(2):128-35. doi: 10.1093/alcalc/agv094. PubMed PMID: 26271115. 2: Beggiato S, O'Connor WT, Tomasini MC, Antonelli T, Loche A, Tanganelli S, Cacciaglia R, Ferraro L. GET73 increases rat extracellular hippocampal CA1 GABA levels through a possible involvement of local mGlu5 receptor. Synapse. 2013 Oct;67(10):678-91. doi: 10.1002/syn.21672. PubMed PMID: 23564259. 3: Loche A, Simonetti F, Lobina C, Carai MA, Colombo G, Castelli MP, Barone D, Cacciaglia R. Anti-Alcohol and Anxiolytic Properties of a New Chemical Entity, GET73. Front Psychiatry. 2012 Feb 14;3:8. doi: 10.3389/fpsyt.2012.00008. PubMed PMID: 22347868; PubMed Central PMCID: PMC3278888. 4: Ferraro L, Beggiato S, Tomasini MC, Antonelli T, Loche A, Tanganelli S. GET73 modulates rat hippocampal glutamate transmission: evidence for a functional interaction with mGluR5. Pharmacol Rep. 2011;63(6):1359-71. PubMed PMID: 22358084. 5: Ferraro L, Loche A, Beggiato S, Tomasini MC, Antonelli T, Colombo G, Lobina C, Carai MA, Porcu A, Castelli MP, Clerici F, Borelli AC, Cacciaglia R, Tanganelli S. The new compound GET73, N-[(4-trifluoromethyl)benzyl]4-methoxybutyramide, Regulates hippocampal Aminoacidergic transmission possibly via an allosteric modulation of mGlu5 receptor. Behavioural evidence of its "anti-alcohol" and anxiolytic properties. Curr Med Chem. 2013;20(27):3339-57. Review. PubMed PMID: 23862615. 6: Ottani A, Leone S, Vergara FB, Tacchi R, Loche A, Bertolini A. Preference for palatable food is reduced by the gamma-hydroxybutyrate analogue GET73, in rats. Pharmacol Res. 2007 Apr;55(4):271-9. PubMed PMID: 17240159. 7: Tacchi R, Ferrari A, Loche A, Bertolini A. Sucrose intake: increase in non-stressed rats and reduction in chronically stressed rats are both prevented by the gamma-hydroxybutyrate (GHB) analogue, GET73. Pharmacol Res. 2008 Jun;57(6):464-8. doi: 10.1016/j.phrs.2008.05.004. PubMed PMID: 18573666.