Synonym
KP 136; KP136; KP-136; AL 136; AL136; AL-136
IUPAC/Chemical Name
2H-1-Benzopyran-2-one, 8-(hexyloxy)-3-(1H-tetrazol-5-yl)-
InChi Key
GUIWTWATPUPDDY-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H18N4O3/c1-2-3-4-5-9-22-13-8-6-7-11-10-12(15-17-19-20-18-15)16(21)23-14(11)13/h6-8,10H,2-5,9H2,1H3,(H,17,18,19,20)
SMILES Code
O=C1C(C2=NN=NN2)=CC3=CC=CC(OCCCCCC)=C3O1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
314.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kuriyama K, Hiyama Y, Ito K, Yoshinaka I, Bito Y. The protective effect of a new antiallergic agent, KP-136 on mast cell activation: a comparison with disodium cromoglycate. Agents Actions. 1988 Dec;25(3-4):321-5. PubMed PMID: 3146215.
2: Hiyama Y, Kuriyama K. [Effect of KP-136 on allergic paw edema in the rat]. Nihon Yakurigaku Zasshi. 1990 Mar;95(3):83-90. Japanese. PubMed PMID: 2141318.
3: Kuriyama K, Hiyama Y, Ito K. Effect of 8-hexyloxy-3-(1H-tetrazol-5-yl)-2H-chromen-2-one [KP-136] on experimental asthma: a comparison with disodium cromoglycate. J Pharmacobiodyn. 1989 Mar;12(3):175-81. PubMed PMID: 2474641.
4: Kuriyama K, Hiyama Y, Ito K, Ichikawa K, Kitada S, Yoshinaka I. [The pharmacological properties of a new anti-allergic agent, KP-136, in cutaneous models]. Nihon Yakurigaku Zasshi. 1987 Apr;89(4):213-24. Japanese. PubMed PMID: 2440785.
5: Kuriyama K, Hiyama Y, Ito K. Antiallergic effects of 4-[2-oxo-3-(1H-tetrazol-5-yl)-2H-chromen-8-yloxy]-bu tyric acid. Jpn J Pharmacol. 1989 Jun;50(2):111-8. PubMed PMID: 2475659.
