Synonym
Pradofloxacin; Veraflox;
IUPAC/Chemical Name
8-Cyano-1-cyclopropyl-6-fluoro-7-((4aS,7aS)-octahydro-6H-pyrrolo(3,4-b)pyridin-6-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
InChi Key
LZLXHGFNOWILIY-APPDUMDISA-N
InChi Code
InChI=1S/C21H21FN4O3/c22-16-6-13-18(26(12-3-4-12)9-15(20(13)27)21(28)29)14(7-23)19(16)25-8-11-2-1-5-24-17(11)10-25/h6,9,11-12,17,24H,1-5,8,10H2,(H,28,29)/t11-,17+/m0/s1
SMILES Code
O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N(C4)C[C@]5([H])[C@@]4([H])CCCN5)=C3C#N)C1=O)O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
396.42
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lees P. Pharmacokinetics, pharmacodynamics and therapeutics of pradofloxacin in the dog and cat. J Vet Pharmacol Ther. 2013 Jun;36(3):209-21. doi: 10.1111/jvp.12036. Epub 2013 Feb 14. PMID: 23406008.
2: Sykes JE, Blondeau JM. Pradofloxacin: a novel veterinary fluoroquinolone for treatment of bacterial infections in cats. Vet J. 2014 Aug;201(2):207-14. doi: 10.1016/j.tvjl.2014.06.008. Epub 2014 Jun 10. PMID: 24997792.
3: Boothe DM, Bush KM, Boothe HW, Davis HA. Pharmacokinetics and pharmacodynamics of oral pradofloxacin administration in dogs. Am J Vet Res. 2018 Dec;79(12):1268-1276. doi: 10.2460/ajvr.79.12.1268. Erratum in: Am J Vet Res. 2019 May;80(5):504. PMID: 30457901.
4: Silley P, Stephan B, Greife HA, Pridmore A. Bactericidal properties of pradofloxacin against veterinary pathogens. Vet Microbiol. 2012 May 25;157(1-2):106-11. doi: 10.1016/j.vetmic.2011.11.027. Epub 2011 Dec 2. PMID: 22209121.
5: Pharmacokinetics and pharmacodynamics of oral pradofloxacin administration in dogs. Am J Vet Res. 2019 May;80(5):504. doi: 10.2460/ajvr.80.5.504. Erratum for: Am J Vet Res. 2018 Dec;79(12):1268-1276. PMID: 31034273.
6: Kizerwetter-Świda M, Chrobak-Chmiel D, Rzewuska M, Binek M. Resistance of canine methicillin-resistant Staphylococcus pseudintermedius strains to pradofloxacin. J Vet Diagn Invest. 2016 Sep;28(5):514-8. doi: 10.1177/1040638716660131. Epub 2016 Jul 22. PMID: 27449131.
7: Taylor E, Trott DJ, Kimble B, Xie S, Govendir M, McLelland DJ. Pharmacokinetic profile of a single dose of an oral pradofloxacin suspension administered to eastern long-necked turtles (Chelodina longicollis). J Vet Pharmacol Ther. 2021 Jul;44(4):503-509. doi: 10.1111/jvp.12933. Epub 2020 Nov 30. PMID: 33283306.
8: Liu X, Lazzaroni C, Aly SA, Thungrat K, Boothe DM. In vitro selection of resistance to pradofloxacin and ciprofloxacin in canine uropathogenic Escherichia coli isolates. Vet Microbiol. 2014 Dec 5;174(3-4):514-522. doi: 10.1016/j.vetmic.2014.10.011. Epub 2014 Oct 25. PMID: 25465666.
9: Hauschild G, Rohn K, Engelhardt E, Sager M, Hardes J, Gosheger G. Pharmacokinetic study on pradofloxacin in the dog - comparison of serum analysis, ultrafiltration and tissue sampling after oral administration. BMC Vet Res. 2013 Feb 14;9:32. doi: 10.1186/1746-6148-9-32. PMID: 23410255; PMCID: PMC3598979.
10: Dowers KL, Tasker S, Radecki SV, Lappin MR. Use of pradofloxacin to treat experimentally induced Mycoplasma hemofelis infection in cats. Am J Vet Res. 2009 Jan;70(1):105-11. doi: 10.2460/ajvr.70.1.105. PMID: 19119955.
