Tinoridine hydrochloride | Y-3642 | CAS#25913-34-2 | 24237-54-5

MedKoo Cat#: 329519 | Name: Tinoridine HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tinoridine, also known as Y-3642, is a non-steroidal anti-inflammatory drug. Tinoridine, at concentrations from 5 microM up to 100 microM, produced a concentration-dependent inhibition on the simultaneous increases in lipid peroxide formation and renin release induced by 50 microM ascorbic acid in the renin granule fraction. On the other hand, indomethacin, hydrocortisone and prednisolone, which had no ability to inhibit the lipid peroxidation in the renin granule fraction, did not influence the release of renin from the granules. These results suggest that tinoridine suppresses renin release by inhibiting the oxidative disintegration of membranes of renin granules.

Chemical Structure

Tinoridine HCl

CAS#25913-34-2 (HCl)

Theoretical Analysis

MedKoo Cat#: 329519

Name: Tinoridine HCl

CAS#: 25913-34-2 (HCl)

Chemical Formula: C17H21ClN2O2S

Exact Mass: 0.0000

Molecular Weight: 352.88

Elemental Analysis: C, 57.86; H, 6.00; Cl, 10.05; N, 7.94; O, 9.07; S, 9.09

Price and Availability

Size	Price	Availability
100mg	USD 650.00	2 Weeks
200mg	USD 1,050.00	2 Weeks
500mg	USD 1,950.00	2 Weeks
1g	USD 2,850.00	2 Weeks
2g	USD 3,850.00	2 Weeks
5g	USD 5,650.00	2 Weeks

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Related CAS #

24237-54-5 (free base) 25913-34-2 (HCl)

Synonym

Tinoridine hydrochloride; Nonflamin; Y-3642; Y 3642; Y3642; Y-3642 hydrochloride; Dimaten.

IUPAC/Chemical Name

2-Amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno(2,3-c)pyridine monohydrochloride

InChi Key

LMAQHEGFQZGATE-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H20N2O2S.ClH/c1-2-21-17(20)15-13-8-9-19(11-14(13)22-16(15)18)10-12-6-4-3-5-7-12;/h3-7H,2,8-11,18H2,1H3;1H

SMILES Code

O=C(C1=C(N)SC2=C1CCN(CC3=CC=CC=C3)C2)OCC.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 352.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Yang S, Zhu Y, Shi Y, Su S, Liang H, Li S, Wu Z, Miao J, Chen Y, Zhang X, Wang X. Screening of NSAIDs library identifies Tinoridine as a novel ferroptosis inhibitor for potential intervertebral disc degeneration therapy. Free Radic Biol Med. 2024 Aug 20;221:245-256. doi: 10.1016/j.freeradbiomed.2024.05.040. Epub 2024 May 26. PMID: 38806104. 2: Dhiman V, Patil K, Velip L, Talluri MVNK, Gananadhamu S. Comprehensive degradation profiling and influence of different oxidizing reagents on tinoridine hydrochloride: Structural characterization of its degradation products using HPLC and HRMS. Rapid Commun Mass Spectrom. 2022 Jan 15;36(1):e9210. doi: 10.1002/rcm.9210. PMID: 34619000. 3: da Cruz RMD, Mendonça-Junior FJB, de Mélo NB, Scotti L, de Araújo RSA, de Almeida RN, de Moura RO. Thiophene-Based Compounds with Potential Anti- Inflammatory Activity. Pharmaceuticals (Basel). 2021 Jul 19;14(7):692. doi: 10.3390/ph14070692. PMID: 34358118; PMCID: PMC8308569. 4: Kalariya PD, Patel PN, Kavya P, Sharma M, Garg P, Srinivas R, Talluri MV. Rapid structural characterization of in vivo and in vitro metabolites of tinoridine using UHPLC-QTOF-MS/MS and in silico toxicological screening of its metabolites. J Mass Spectrom. 2015 Nov;50(11):1222-33. doi: 10.1002/jms.3640. PMID: 26505767. 5: Tanaka H, Nakagawa M, Takeuchi K, Okabe S. Effects of mepirizole and basic antiinflammatory drugs on HCl-ethanol-induced gastric lesions in rats. Dig Dis Sci. 1989 Feb;34(2):238-45. doi: 10.1007/BF01536058. PMID: 2914545. 6: Shimada O, Yasuda H. Hydroxyl radical scavenging action of tinoridine. Agents Actions. 1986 Nov;19(3-4):208-14. doi: 10.1007/BF01966208. PMID: 3030074. 7: Yasuda H, Izumi N, Shimada O, Maruyama Y, Kobayakawa T. Protection against hepatic injury by a novel spiropiperidine derivative. Toxicol Appl Pharmacol. 1986 Sep 30;85(3):398-406. doi: 10.1016/0041-008x(86)90347-9. PMID: 3764923. 8: Matsumura Y, Miyawaki N, Ohno Y, Sasaki Y, Shimizu T, Morimoto S. Effects of tinoridine on lipid peroxidation and renin release in the rat renin granule fraction. J Pharmacobiodyn. 1985 Jul;8(7):532-8. doi: 10.1248/bpb1978.8.532. PMID: 3906080. 9: Morisaki N, Lindsey JA, Stitts JM, Zhang H, Cornwell DG. Fatty acid metabolism and cell proliferation. V. Evaluation of pathways for the generation of lipid peroxides. Lipids. 1984 Jun;19(6):381-94. doi: 10.1007/BF02537399. PMID: 6429469. 10: Delhotal B, Flouvat B, Potaux L. Pharmacokinetics of tinoridine after oral administration to healthy subjects and patients with renal failure. Int J Clin Pharmacol Ther Toxicol. 1983 Aug;21(8):410-6. PMID: 6605310. 11: Fukawa K, Kanezuka T, Ohba S, Kawano O, Hibi M, Misaki N, Sawabe T. Studies on an anti-inflammatory agent. III. Pharmacological investigations of a new non- steroidal anti-inflammatory agent: 2-oxo-3-[4-(1-oxo-2-isoindolinyl)-phenyl]-butanamide (GP 650). Arzneimittelforschung. 1982;32(3):225-30. PMID: 6979341. 12: Yasuda H, Izumi N, Shimada O, Kobayakawa T, Nakanishi M. The protective effect of tinoridine against carbon tetrachloride hepatotoxicity. Toxicol Appl Pharmacol. 1980 Mar 15;52(3):407-13. doi: 10.1016/0041-008x(80)90335-x. PMID: 6892737. 13: Shimada O, Yasuda H. Lipid peroxidation and its inhibition by tinoridine, II. Ascorbic acid-induced lipid peroxidation of rat liver mitochondria. Biochim Biophys Acta. 1979 Mar 29;572(3):531-6. PMID: 582014. 14: Goto K, Hisadome M, Maruyama Y, Imamura H. Effects of 2-(4-(2-imidazo[1,2-a]pyridyl)phenyl) propionic acid (Y-9213) and anti- inflammatory drugs on erythrocytes, polymorphonuclear leukocytes and lysosomes in vitro. Jpn J Pharmacol. 1978 Jun;28(3):433-46. doi: 10.1254/jjp.28.433. PMID: 702946. 15: Shimada O, Yasuda H. Lipid peroxidation and its inhibition by tinoridine. I. Lipid peroxidation-induced disintegration of microsomal membrane and cytochrome P-450 in rat liver. Biochim Biophys Acta. 1977 Oct 24;489(1):163-72. doi: 10.1016/0005-2760(77)90242-9. PMID: 20972. 16: Goto K, Hisadome M, Imamura H. Effect of tinoridine on stability of rat liver and kidney lysosomes, and liver parenchymal cells. Biochem Pharmacol. 1977 Jan 1;26(1):11-8. doi: 10.1016/0006-2952(77)90123-x. PMID: 576205. 17: Nakanishi M, Goto K, Hisadome M. [Studies on anti-inflammatory agents. XXIX. Inhibitory effects of Tinoridine on release of lysosome enzymes and lipid peroxidation in rat liver (author's transl)]. Yakugaku Zasshi. 1975 Aug;95(8):936-43. Japanese. doi: 10.1248/yakushi1947.95.8_936. PMID: 1242397. 18: Nakanishi M, Goto K. [Studies on anti-inflammatory agents. XXIII. Membrane stabilizing action of tinoridine on lysosomes of polymorphonuclear leucocytes from guinea-pigs (author's transl)]. Yakugaku Zasshi. 1974 Jun;94(6):660-5. Japanese. doi: 10.1248/yakushi1947.94.6_660. PMID: 4472612. 19: Fujita T, Yasuda M. Effect of 2-amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno (2,3-C) pyridine (tinoridine) on fatty acid composition of liver lysosomes from a vitamin E deficient diet to rats. Jpn J Pharmacol. 1973 Dec;23(6):899-901. doi: 10.1254/jjp.23.899. PMID: 4544701.