Related CAS #
24237-54-5 (free base); 25913-34-2 (HCl)
Synonym
Tinoridine Free Base; NSC158555; NSC-158555; NSC 158555; Y3642; Y-3642; Y 3642
IUPAC/Chemical Name
ethyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate
InChi Key
PFENFDGYVLAFBR-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H20N2O2S/c1-2-21-17(20)15-13-8-9-19(11-14(13)22-16(15)18)10-12-6-4-3-5-7-12/h3-7H,2,8-11,18H2,1H3
SMILES Code
CCOC(c1c2c(CN(CC2)Cc3ccccc3)sc1N)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
316.42
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Shimada O, Yasuda H. Hydroxyl radical scavenging action of tinoridine. Agents Actions. 1986 Nov;19(3-4):208-14. doi: 10.1007/BF01966208. PMID: 3030074.
2: Kalariya PD, Patel PN, Kavya P, Sharma M, Garg P, Srinivas R, Talluri MV. Rapid structural characterization of in vivo and in vitro metabolites of tinoridine using UHPLC-QTOF-MS/MS and in silico toxicological screening of its metabolites. J Mass Spectrom. 2015 Nov;50(11):1222-33. doi: 10.1002/jms.3640. PMID: 26505767.
3: Matsumura Y, Miyawaki N, Ohno Y, Sasaki Y, Shimizu T, Morimoto S. Effects of tinoridine on lipid peroxidation and renin release in the rat renin granule fraction. J Pharmacobiodyn. 1985 Jul;8(7):532-8. doi: 10.1248/bpb1978.8.532. PMID: 3906080.
4: Goto K, Hisadome M, Imamura H. Effect of tinoridine on stability of rat liver and kidney lysosomes, and liver parenchymal cells. Biochem Pharmacol. 1977 Jan 1;26(1):11-8. doi: 10.1016/0006-2952(77)90123-x. PMID: 576205.
5: Delhotal B, Flouvat B, Potaux L. Pharmacokinetics of tinoridine after oral administration to healthy subjects and patients with renal failure. Int J Clin Pharmacol Ther Toxicol. 1983 Aug;21(8):410-6. PMID: 6605310.
6: Goto K, Hisadome M, Maruyama Y, Imamura H. Effects of 2-(4-(2-imidazo[1,2-a]pyridyl)phenyl) propionic acid (Y-9213) and anti- inflammatory drugs on erythrocytes, polymorphonuclear leukocytes and lysosomes in vitro. Jpn J Pharmacol. 1978 Jun;28(3):433-46. doi: 10.1254/jjp.28.433. PMID: 702946.
7: Yasuda H, Izumi N, Shimada O, Kobayakawa T, Nakanishi M. The protective effect of tinoridine against carbon tetrachloride hepatotoxicity. Toxicol Appl Pharmacol. 1980 Mar 15;52(3):407-13. doi: 10.1016/0041-008x(80)90335-x. PMID: 6892737.
8: Shimada O, Yasuda H. Lipid peroxidation and its inhibition by tinoridine, II. Ascorbic acid-induced lipid peroxidation of rat liver mitochondria. Biochim Biophys Acta. 1979 Mar 29;572(3):531-6. PMID: 582014.
9: Shimada O, Yasuda H. Lipid peroxidation and its inhibition by tinoridine. I. Lipid peroxidation-induced disintegration of microsomal membrane and cytochrome P-450 in rat liver. Biochim Biophys Acta. 1977 Oct 24;489(1):163-72. doi: 10.1016/0005-2760(77)90242-9. PMID: 20972.
10: Tanaka H, Nakagawa M, Takeuchi K, Okabe S. Effects of mepirizole and basic antiinflammatory drugs on HCl-ethanol-induced gastric lesions in rats. Dig Dis Sci. 1989 Feb;34(2):238-45. doi: 10.1007/BF01536058. PMID: 2914545.
