Synonym
BAY-299; BAY 299; BAY299.
IUPAC/Chemical Name
6-(3-Hydroxypropyl)-2-(1,3,6-trimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione
InChi Key
OFWWWKWUCDUISA-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H23N3O4/c1-14-12-20-21(27(3)25(32)26(20)2)13-19(14)28-23(30)17-8-4-7-16-15(6-5-11-29)9-10-18(22(16)17)24(28)31/h4,7-10,12-13,29H,5-6,11H2,1-3H3
SMILES Code
O=C1N(C2=C(C)C=C(N3C)C(N(C)C3=O)=C2)C(C4=CC=C(CCCO)C5=CC=CC1=C45)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
comments |
| Solubility |
| DMSO |
30.0 |
69.85 |
|
| DMF |
30.0 |
69.85 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
429.48
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Zhou L, Yao Q, Ma L, Li H, Chen J. TAF1 inhibitor Bay-299 induces cell death
in acute myeloid leukemia. Transl Cancer Res. 2021 Dec;10(12):5307-5318. doi:
10.21037/tcr-21-2295. PMID: 35116379; PMCID: PMC8798726.
2: Zhang S, Liu X, Chen W, Zhang K, Wu Q, Wei Y. Targeting TAF1 with BAY-299
induces antitumor immunity in triple-negative breast cancer. Biochem Biophys Res
Commun. 2023 Jul 12;665:55-63. doi: 10.1016/j.bbrc.2023.04.100. Epub 2023 Apr
28. PMID: 37148745.
3: Bouché L, Christ CD, Siegel S, Fernández-Montalván AE, Holton SJ, Fedorov O,
Ter Laak A, Sugawara T, Stöckigt D, Tallant C, Bennett J, Monteiro O, Díaz-Sáez
L, Siejka P, Meier J, Pütter V, Weiske J, Müller S, Huber KVM, Hartung IV,
Haendler B. Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2
and TAF1/TAF1L Bromodomains. J Med Chem. 2017 May 11;60(9):4002-4022. doi:
10.1021/acs.jmedchem.7b00306. Epub 2017 May 1. PMID: 28402630; PMCID:
PMC5443610.
