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MedKoo Cat#: 526455 | Name: Ticolubant

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ticolubant is a leukotriene B4 antagonist.

Chemical Structure

Ticolubant
Ticolubant
CAS#154413-61-3

Theoretical Analysis

MedKoo Cat#: 526455

Name: Ticolubant

CAS#: 154413-61-3

Chemical Formula: C23H19Cl2NO3S

Exact Mass: 459.0463

Molecular Weight: 460.37

Elemental Analysis: C, 60.01; H, 4.16; Cl, 15.40; N, 3.04; O, 10.43; S, 6.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ticolubant
IUPAC/Chemical Name
2-Propenoic acid, 3-(6(((2,6-dichlorophenyl)thio)methyl)-3-(2-phenylethoxy)-2-pyridinyl)-, (E)-
InChi Key
ZJLFOOWTDISDIO-ZRDIBKRKSA-N
InChi Code
InChI=1S/C23H19Cl2NO3S/c24-18-7-4-8-19(25)23(18)30-15-17-9-11-21(20(26-17)10-12-22(27)28)29-14-13-16-5-2-1-3-6-16/h1-12H,13-15H2,(H,27,28)/b12-10+
SMILES Code
O=C(O)/C=C/C1=NC(CSC2=C(Cl)C=CC=C2Cl)=CC=C1OCCC3=CC=CC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 460.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kenny JR, Maggs JL, Tettey JN, Harrell AW, Parker SG, Clarke SE, Park BK. Formation and protein binding of the acyl glucuronide of a leukotriene B4 antagonist (SB-209247): relation to species differences in hepatotoxicity. Drug Metab Dispos. 2005 Feb;33(2):271-81. PubMed PMID: 15523047. 2: Davis HM, Carpenter DC, Stahl JM, Zhang W, Hynicka WP, Griswold DE. Human granulocyte CD11b expression as a pharmacodynamic biomarker of inflammation. J Immunol Methods. 2000 Jun 23;240(1-2):125-32. PubMed PMID: 10854607. 3: Daines RA, Chambers PA, Foley JJ, Griswold DE, Kingsbury WD, Martin LD, Schmidt DB, Sham KK, Sarau HM. (E)-3-[6-[[(2,6-dichlorophenyl)thio]methyl]-3-(2-phenylethoxy)-2- pyridinyl]-2-propenoic acid: a high-affinity leukotriene B4 receptor antagonist with oral antiinflammatory activity. J Med Chem. 1996 Sep 13;39(19):3837-41. PubMed PMID: 8809171. 4: Sarau HM, Foley JJ, Schmidt DB, Tzimas MN, Martin LD, Daines RA, Chambers PA, Kingsbury WD, Griswold DE. SB 209247, a high affinity LTB4 receptor antagonist demonstrating potent antiinflammatory activity. Adv Prostaglandin Thromboxane Leukot Res. 1995;23:275-7. PubMed PMID: 7732852.