Synonym
Cgp 31608; CGP31608; CGP-31608
IUPAC/Chemical Name
4-Thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(aminomethyl)-6-(1-hydroxyethyl)-7-oxo-, (5R-(5-alpha,6-alpha(R*)))-
InChi Key
RXCNILVLOHRALM-UWBRJAPDSA-N
InChi Code
InChI=1S/C9H12N2O4S/c1-3(12)5-7(13)11-6(9(14)15)4(2-10)16-8(5)11/h3,5,8,12H,2,10H2,1H3,(H,14,15)/t3-,5+,8-/m1/s1
SMILES Code
O=C(C(N12)=C(CN)S[C@]2([H])[C@@H]([C@H](O)C)C1=O)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
244.27
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Wise R, Andrews JM, Piddock LJ. In vitro activity of CGP 31608, a new penem. Antimicrob Agents Chemother. 1987 Feb;31(2):267-73. doi: 10.1128/aac.31.2.267. PMID: 3105451; PMCID: PMC174704.
2: Neu HC, Chin NX, Neu NM. In vitro activity and beta-lactamase stability of a new penem, CGP 31608. Antimicrob Agents Chemother. 1987 Apr;31(4):558-69. doi: 10.1128/aac.31.4.558. PMID: 3496845; PMCID: PMC174777.
3: Eliopoulos GM, Wennersten C, Reiszner E, Moellering RC Jr. Comparative in vitro activity of CGP 31608, a new penem antibiotic. Antimicrob Agents Chemother. 1987 Aug;31(8):1188-93. doi: 10.1128/aac.31.8.1188. PMID: 3498437; PMCID: PMC174901.
4: Hamilton-Miller JM. Chemical and microbiologic aspects of penems, a distinct class of beta-lactams: focus on faropenem. Pharmacotherapy. 2003 Nov;23(11):1497-507. doi: 10.1592/phco.23.14.1497.31937. PMID: 14620395.
5: Sachdeva M, Hackbarth C, Stella FB, Chambers HF. Comparative activity of CGP 31608, nafcillin, cefamandole, imipenem, and vancomycin against methicillin- susceptible and methicillin-resistant staphylococci. Antimicrob Agents Chemother. 1987 Oct;31(10):1549-52. doi: 10.1128/aac.31.10.1549. PMID: 3481245; PMCID: PMC174987.
6: Reeves DS, Bywater MJ, Holt HA. Activity in vitro of CGP 31608, a new penem antibacterial agent. J Antimicrob Chemother. 1987 Aug;20(2):165-78. doi: 10.1093/jac/20.2.165. PMID: 3667480.
7: Cozens RM, Markiewicz Z, Tuomanen E. Role of autolysins in the activities of imipenem and CGP 31608, a novel penem, against slowly growing bacteria. Antimicrob Agents Chemother. 1989 Oct;33(10):1819-21. doi: 10.1128/aac.33.10.1819. PMID: 2574024; PMCID: PMC172763.
8: Wise R, Webberley JM, Andrews JM, Ashby JP. The pharmacokinetics and tissue penetration of intravenously administered CGP 31608. J Antimicrob Chemother. 1988 Jan;21(1):85-91. doi: 10.1093/jac/21.1.85. PMID: 3356625.
9: Van der Auwera P, Ernst F, Grenier P, Glupczynski Y, Husson M, Klastersky J. In-vitro activity of two new carbapenems FCE 22101 and CGP 31608 in comparison with imipenem. J Antimicrob Chemother. 1987 Aug;20(2):179-89. doi: 10.1093/jac/20.2.179. PMID: 3478328.
10: McConnell ME, Sarria-Cepeda S, Rouse MS, Henry NK, Wilson WR. Comparative in vitro activity of the new penem CGP 31608. Eur J Clin Microbiol. 1987 Jun;6(3):313-5. doi: 10.1007/BF02017622. PMID: 3622498.
