Fosalvudine tidoxil | CAS#763903-67-9 | nucleoside reverse transcriptase inhibitor | HIV

MedKoo Cat#: 530002 | Name: Fosalvudine tidoxil

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fosalvudine tidoxil is a nucleoside reverse transcriptase inhibitor potentially for the treatment of HIV infection.

Chemical Structure

Fosalvudine tidoxil

CAS#763903-67-9

Theoretical Analysis

MedKoo Cat#: 530002

Name: Fosalvudine tidoxil

CAS#: 763903-67-9

Chemical Formula: C35H64FN2O8PS

Exact Mass: 722.4100

Molecular Weight: 722.94

Elemental Analysis: C, 58.15; H, 8.92; F, 2.63; N, 3.88; O, 17.70; P, 4.28; S, 4.43

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

763903-67-9

Synonym

HDP-99.0003; HDP-990003; HDP 99.0003; HDP 990003; HDP99.0003; HDP990003; Fosalvudine tidoxil;

IUPAC/Chemical Name

(R)-2-(decyloxy)-3-(dodecylthio)propyl (((2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl) hydrogen phosphate

InChi Key

JHXLLEDIXXOJQD-VBWFMVIDSA-N

InChi Code

InChI=1S/C35H64FN2O8PS/c1-4-6-8-10-12-14-15-17-19-21-23-48-28-30(43-22-20-18-16-13-11-9-7-5-2)26-44-47(41,42)45-27-32-31(36)24-33(46-32)38-25-29(3)34(39)37-35(38)40/h25,30-33H,4-24,26-28H2,1-3H3,(H,41,42)(H,37,39,40)/t30-,31+,32-,33-/m1/s1

SMILES Code

O=P(OC[C@H]1O[C@@H](N(C(N2)=O)C=C(C)C2=O)C[C@@H]1F)(OC[C@@H](OCCCCCCCCCC)CSCCCCCCCCCCCC)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 722.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Venhoff AC, Lebrecht D, Reuss FU, Heckl-Ostreicher B, Wehr R, Walker UA, Venhoff N. Mitochondrial DNA depletion in rat liver induced by fosalvudine tidoxil, a novel nucleoside reverse transcriptase inhibitor prodrug. Antimicrob Agents Chemother. 2009 Jul;53(7):2748-51. doi: 10.1128/AAC.00364-09. PubMed PMID: 19433557; PubMed Central PMCID: PMC2704664.