Synonym
Clanfenur; Clanfenurum; NSC603108; NSC 603108; NSC-603108;
IUPAC/Chemical Name
N-((4-chlorophenyl)carbamoyl)-2-(dimethylamino)-6-fluorobenzamide
InChi Key
SRLPZQAEBMZCIJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H15ClFN3O2/c1-21(2)13-5-3-4-12(18)14(13)15(22)20-16(23)19-11-8-6-10(17)7-9-11/h3-9H,1-2H3,(H2,19,20,22,23)
SMILES Code
CN(C1=CC=CC(F)=C1C(NC(NC2=CC=C(Cl)C=C2)=O)=O)C
Appearance
White to off-white solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
335.76
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Sluiter C, Kettenes-van den Bosch JJ, Hop E, van der Houwen OA, Underberg WJ,
Bult A. Degradation study of the investigational anticancer drug clanfenur. Int J
Pharm. 1999 Aug 20;185(2):227-35. PubMed PMID: 10460918.
2: Jonkman-de Vries JD, Van den Bemt BJ, ten Bokkel-Huinink WW, Underberg WJ,
Kettenes-van den Bosch JJ, Henrar RE, Bult A, Beijnen JH. Pharmaceutical
development of a parenteral formulation of the investigational anticancer drug
clanfenur. PDA J Pharm Sci Technol. 1997 Mar-Apr;51(2):89-95. PubMed PMID:
9146040.
3: Noteborn HP, Varossieau FJ, Monshouwer M, Brands R, Pinedo HM. A
reversed-phase high-performance liquid chromatographic method for the
determination of Clanfenur in rat and human plasma. J Pharm Biomed Anal. 1994
Jul;12(7):937-42. PubMed PMID: 7981324.
4: Jenkins VK, Juneja HS, Ives K, Lee S, Perry RR. Effects of diflubenzuron and
clanfenur on mouse bone marrow cells. Invest New Drugs. 1993 Nov;11(4):279-89.
PubMed PMID: 8157470.
