MedKoo Cat#: 526441 | Name: Terlakiren

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Terlakiren is a renin inhibitor.

Chemical Structure

Terlakiren
Terlakiren
CAS#119625-78-4

Theoretical Analysis

MedKoo Cat#: 526441

Name: Terlakiren

CAS#: 119625-78-4

Chemical Formula: C31H48N4O7S

Exact Mass: 620.3244

Molecular Weight: 620.81

Elemental Analysis: C, 59.98; H, 7.79; N, 9.03; O, 18.04; S, 5.16

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Terlakiren
IUPAC/Chemical Name
L-Cysteinamide, N-(4-morpholinylcarbonyl)-L-phenylalanyl-N-(1-(cyclohexylmethyl)-2-hydroxy-3-(1-methylethoxy)-3-oxopropyl)-S-methyl-, (R-(R*,S*))-
InChi Key
InChi Code
SMILES Code
O=C(N)[C@H](CSC)N(C([C@H](CC1=CC=CC=C1)NC(N2CCOCC2)=O)=O)[C@@H](CC3CCCCC3)[C@@H](O)C(OC(C)C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 620.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Mangiapane ML, Peters BR. Role of nitric oxide in responses to renin-angiotensin system inhibition in sodium-depleted guinea pig and rat. Clin Exp Hypertens. 1998 Feb;20(2):141-63. PubMed PMID: 9533611. 2: Allen MC, Stafford CG, Nocerini MR. Quantitation of 4-cyclohexyl-2-hydroxy-3-(3-methylsulfanyl-2- [2-[(morpholine-4-carbonyl)amino]-3-phenylpropionylamino]propi onylamino ) butyric acid isopropyl ester (CP-80,794), a renin inhibitor, and its hydrolytic cleavage metabolite 2-[(morpholine-4-carbonyl)amino]-3-phenylpropionic acid (CP-84,364) in dog and human plasma by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl. 1997 Aug 29;696(2):243-51. PubMed PMID: 9323544. 3: Shannon RP, Friedrich S, Mathier M, Knight DR. Effects of renin inhibition compared to angiotensin converting enzyme inhibition in conscious dogs with pacing-induced heart failure. Cardiovasc Res. 1997 Jun;34(3):464-72. PubMed PMID: 9231029. 4: Pitts JE, Crawford MD, Nugent PG, Wester RT, Cooper JB, Mantyla A, Fagerstrom R, Nevalainen H. The three-dimensional X-ray crystal structure of the aspartic proteinase native to Trichoderma reesei complexed with a renin inhibitor CP-80794. Adv Exp Med Biol. 1995;362:543-7. PubMed PMID: 8540369. 5: Hoover DJ, Lefker BA, Rosati RL, Wester RT, Kleinman EF, Bindra JS, Holt WF, Murphy WR, Mangiapane ML, Hockel GM, et al. Discovery of inhibitors of human renin with high oral bioavailability. Adv Exp Med Biol. 1995;362:167-80. PubMed PMID: 8540316. 6: Fossa AA, Weinberg LJ, Barber RL, Rauch AL, Nocerini MR, Murphy WR, Swindell AC. Synergistic effect on reduction in blood pressure with coadministration of the renin inhibitor, CP-80,794, and the angiotensin converting enzyme inhibitor, captopril. J Cardiovasc Pharmacol. 1992 Jul;20(1):75-82. PubMed PMID: 1383634.