Merbromin | CAS# 129-16-8 | topical antiseptic

MedKoo Cat#: 413883 | Name: Merbromin

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Merbromin is an organomercuric disodium salt compound used as a topical antiseptic for minor cuts and scrapes and as a biological dye. Readily available in most countries, it is no longer sold in Switzerland, Brazil, France, Iran, Germany, Australia, and the United States due to its mercury content.

Chemical Structure

Merbromin

CAS#129-16-8

Theoretical Analysis

MedKoo Cat#: 413883

Name: Merbromin

CAS#: 129-16-8

Chemical Formula: C20H8Br2HgNa2O6

Exact Mass: 749.8189

Molecular Weight: 750.66

Elemental Analysis: C, 32.00; H, 1.07; Br, 21.29; Hg, 26.72; Na, 6.13; O, 12.79

Price and Availability

Size	Price	Availability	Quantity
1g	USD 250.00	2 Weeks

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Related CAS #

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Synonym

Merbromin; DOMF; HSDB6800; HSDB-6800; HSDB 6800

IUPAC/Chemical Name

sodium (2',7'-dibromo-3',6'-dioxido-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthen]-4'-yl)(hydroxy)mercury

InChi Key

JXQGSRKVFQSVTR-UHFFFAOYSA-K

InChi Code

InChI=1S/C20H9Br2O5.Hg.2Na.H2O/c21-13-5-11-17(7-15(13)23)26-18-8-16(24)14(22)6-12(18)20(11)10-4-2-1-3-9(10)19(25)27-20;;;;/h1-7,23-24H;;;;1H2/q;3*+1;/p-3

SMILES Code

O[Hg]c1c(Oc2c(C34OC(c5c4cccc5)=O)cc(Br)c([O-])c2)c3cc(Br)c1[O-].[Na+].[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Merbromin acts as a topical antiseptic for minor cuts and scrapes and as a biological dye.

In vitro activity:

Herein, about 6000 compounds were analyzed by high-throughput screening using enzyme activity model, and Merbromin, an antibacterial agent, was identified as a potent inhibitor of 3CLpro. Merbromin strongly inhibited the proteolytic activity of 3CLpro but not the other three proteases Proteinase K, Trypsin and Papain. Michaelis-Menten kinetic analysis showed that Merbromin was a mixed-type inhibitor of 3CLpro, due to its ability of increasing the KM and decreasing the Kcat of 3CLpro. Reference: Biochem Biophys Res Commun. 2022 Feb 5;591:118-123. https://pubmed.ncbi.nlm.nih.gov/35007835/

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMSO	6.7	8.89

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 750.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Chen J, Zhang Y, Zeng D, Zhang B, Ye X, Zeng Z, Zhang XK, Wang Z, Zhou H. Merbromin is a mixed-type inhibitor of 3-chyomotrypsin like protease of SARS-CoV-2. Biochem Biophys Res Commun. 2022 Feb 5;591:118-123. doi: 10.1016/j.bbrc.2021.12.108. Epub 2021 Dec 30. PMID: 35007835; PMCID: PMC8716398. 2. Alkhashrom S, Kicuntod J, Häge S, Schweininger J, Muller YA, Lischka P, Marschall M, Eichler J. Exploring the Human Cytomegalovirus Core Nuclear Egress Complex as a Novel Antiviral Target: A New Type of Small Molecule Inhibitors. Viruses. 2021 Mar 12;13(3):471. doi: 10.3390/v13030471. PMID: 33809234; PMCID: PMC7998563.

In vitro protocol:

In vivo protocol:

TBD