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MedKoo Cat#: 530124 | Name: BTS74398 citrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BTS-74398 is a serotonin/dopamine/norepinephrine reuptake inhibitior potentially for the treatment of Parkinson's Disease. It inhibits the synaptic reuptake of dopamine, serotonin and noradrenaline, making it a triple reuptake inhibitor. Note: Many web page listed BTS74398 with a wrong structure (it was listed CAS#548491-50-5 with a incorrect structure, which had CAS#2733948-96-2). However, according to Scifinder, the CAS# for BTS74398 citrate is 548491-50-5.

Chemical Structure

BTS74398 citrate
BTS74398 citrate
CAS#548491-50-5 (citrate)

Theoretical Analysis

MedKoo Cat#: 530124

Name: BTS74398 citrate

CAS#: 548491-50-5 (citrate)

Chemical Formula: C25H35Cl2NO8S

Exact Mass:

Molecular Weight: 580.51

Elemental Analysis: C, 51.73; H, 6.08; Cl, 12.21; N, 2.41; O, 22.05; S, 5.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
548491-50-5 (citrate) 548491-49-2 (free base) 2733948-96-2
Synonym
BTS74398; BTS 74398; BTS-74398; BTS74,398; BTS 74,398; BTS-74,398; BTS74398 citrate; SPD473; SPD 473; SPD-473;
IUPAC/Chemical Name
Ethanone, 1-[1-(3,4-dichlorophenyl)cyclobutyl]-2-[[3-(diethylamino)propyl]thio]-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
InChi Key
UZRGKFGYFHQJAW-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H27Cl2NOS.C6H8O7/c1-3-22(4-2)11-6-12-24-14-18(23)19(9-5-10-19)15-7-8-16(20)17(21)13-15;7-3(8)1-6(13,5(11)12)2-4(9)10/h7-8,13H,3-6,9-12,14H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
SMILES Code
CCN(CCCSCC(C1(C2=CC=C(Cl)C(Cl)=C2)CCC1)=O)CC.O=C(CC(C(O)=O)(O)CC(O)=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related CAS# 161189-99-7(SPD-473 Free) 161190-26-7(SPD-473 citrate)

Preparing Stock Solutions

The following data is based on the product molecular weight 580.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lane EL, Cheetham S, Jenner P. Dopamine uptake inhibitor-induced rotation in 6-hydroxydopamine-lesioned rats involves both D1 and D2 receptors but is modulated through 5-hydroxytryptamine and noradrenaline receptors. J Pharmacol Exp Ther. 2005 Mar;312(3):1124-31. PubMed PMID: 15542624. 2: Hansard MJ, Smith LA, Jackson MJ, Cheetham SC, Jenner P. The monoamine reuptake inhibitor BTS 74 398 fails to evoke established dyskinesia but does not synergise with levodopa in MPTP-treated primates. Mov Disord. 2004 Jan;19(1):15-21. PubMed PMID: 14743355. 3: Lane EL, Cheetham SC, Jenner P. Repeated administration of the monoamine reuptake inhibitor BTS 74 398 induces ipsilateral circling in the 6-hydroxydopamine lesioned rat without sensitizing motor behaviours. Eur J Neurosci. 2005 Jan;21(1):179-86. PubMed PMID: 15654855. 4: Lane EL, Cheetham S, Jenner P. Striatal output markers do not alter in response to circling behaviour in 6-OHDA lesioned rats produced by acute or chronic administration of the monoamine uptake inhibitor BTS 74 398. J Neural Transm (Vienna). 2008;115(3):423-9. doi: 10.1007/s00702-007-0854-x. PubMed PMID: 18250952.