MedKoo Cat#: 598205 | Name: Benoxinate HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Benoxinate HCl is a local anesthetic used in ophthalmology to numb the surface of the eye for a variety of procedures.

Chemical Structure

Benoxinate HCl
Benoxinate HCl
CAS#5987-82-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 598205

Name: Benoxinate HCl

CAS#: 5987-82-6 (HCl)

Chemical Formula: C17H29ClN2O3

Exact Mass: 0.0000

Molecular Weight: 344.88

Elemental Analysis: C, 59.21; H, 8.48; Cl, 10.28; N, 8.12; O, 13.92

Price and Availability

Size Price Availability Quantity
1g USD 250.00 2 Weeks
5g USD 550.00 2 Weeks
10g USD 850.00 2 Weeks
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Synonym
Benoxinate hydrochloride; Benoxinate HCl; Lacrimin; Novesin; Minims Benoxinate; Oxbarukain; Oxybuprocaine (hydrochloride); Oxybuprocaine; Benoxinate; Dorsacaine
IUPAC/Chemical Name
2-(diethylamino)ethyl 4-amino-3-butoxybenzoate hydrochloride
InChi Key
PRGUDWLMFLCODA-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H28N2O3.ClH/c1-4-7-11-21-16-13-14(8-9-15(16)18)17(20)22-12-10-19(5-2)6-3;/h8-9,13H,4-7,10-12,18H2,1-3H3;1H
SMILES Code
O=C(OCCN(CC)CC)C1=CC=C(N)C(OCCCC)=C1.[H]Cl
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 344.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bentley CR, Larke JR. Apparent respiration rate of the human corneal epithelium with tetracaine HCl and benoxinate HCl. Am J Optom Physiol Opt. 1983 Dec;60(12):960-3. PubMed PMID: 6660279. 2: El-Gindy A. First derivative spectrophotometric and LC determination of benoxinate hydrochloride and its degradation products. J Pharm Biomed Anal. 2000 Mar;22(2):215-34. PubMed PMID: 10719904. 3: Carney LG, O'Leary DJ, Millodot M. Effect of topical anaesthesia on corneal epithelial fragility. Int Ophthalmol. 1984 Jun;7(2):71-3. PubMed PMID: 6480223. 4: Kleinfeld J, Ellis PP. Inhibition of microorganisms by topical anesthetics. Appl Microbiol. 1967 Nov;15(6):1296-8. PubMed PMID: 16349737; PubMed Central PMCID: PMC547186. 5: Almubrad TM, Alshehri FH, Ogbuehi KC, Osuagwu UL. Comparison of the influence of nonpreserved oxybuprocaine and a preserved artificial tear (thera tears) on human corneal thickness measured by two pachymeters. J Ocul Pharmacol Ther. 2013 Jun;29(5):462-8. doi: 10.1089/jop.2012.0215. Epub 2013 Jan 18. PubMed PMID: 23331053. 6: Ogbuehi KC, Chijuka JC, Osuagwu UL. Changes in central corneal thickness values after instillation of oxybuprocaine hydrochloride 0.4%. Cont Lens Anterior Eye. 2012 Oct;35(5):199-202. doi: 10.1016/j.clae.2012.05.004. Epub 2012 Jun 15. PubMed PMID: 22704944. 7: Alani SD. The ophthalmic rod: a new ophthalmic drug delivery system I. Graefes Arch Clin Exp Ophthalmol. 1990;228(4):297-301. PubMed PMID: 2205544. 8: Lipshitz I, Loewenstein A, Lazar M. [Excimer laser correction of myopia]. Harefuah. 1993 Jul;125(1-2):4-6, 64. Hebrew. PubMed PMID: 8225068.