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MedKoo Cat#: 527202 | Name: LMI-1195

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LMI-1195, also known as flubrobenguane (18F), is a 18F-labeled ligand for the norepinephrine transporter. LMI-1195 is used for mapping cardiac nerve terminals in vivo using positron emission tomography (PET). The (18)F label facilitates the imaging advantages of PET over SPECT technology while allowing centralized manufacturing. Highly specific neural uptake of (18)F-LMI1195 has previously been established, but the retention kinetics are not yet fully understood.

Chemical Structure

LMI-1195
LMI-1195
CAS#1037359-47-9

Theoretical Analysis

MedKoo Cat#: 527202

Name: LMI-1195

CAS#: 1037359-47-9

Chemical Formula: C11H15Br18FN3O

Exact Mass: 302.0408

Molecular Weight: 303.17

Elemental Analysis: C, 43.58; H, 4.99; Br, 26.36; F, 5.94; N, 13.86; O, 5.28

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
LMI-1195, LMI 1195, LMI1195; flubrobenguane (18F)
IUPAC/Chemical Name
1-(3-bromo-4-(3-(fluoro-18F)propoxy)benzyl)guanidine
InChi Key
ZYULQCDNUYJBRI-HSGWXFLFSA-N
InChi Code
InChI=1S/C11H15BrFN3O/c12-9-6-8(7-16-11(14)15)2-3-10(9)17-5-1-4-13/h2-3,6H,1,4-5,7H2,(H4,14,15,16)/i13-1
SMILES Code
BrC1=C(OCCC[18F])C=CC(CNC(N)=N)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 303.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Werner RA, Rischpler C, Onthank D, Lapa C, Robinson S, Samnick S, Javadi M, Schwaiger M, Nekolla SG, Higuchi T. Retention Kinetics of the 18F-Labeled Sympathetic Nerve PET Tracer LMI1195: Comparison with 11C-Hydroxyephedrine and 123I-MIBG. J Nucl Med. 2015 Sep;56(9):1429-33. doi: 10.2967/jnumed.115.158493. PubMed PMID: 26182969. 2: Yu M, Bozek J, Lamoy M, Guaraldi M, Silva P, Kagan M, Yalamanchili P, Onthank D, Mistry M, Lazewatsky J, Broekema M, Radeke H, Purohit A, Cdebaca M, Azure M, Cesati R, Casebier D, Robinson SP. Evaluation of LMI1195, a novel 18F-labeled cardiac neuronal PET imaging agent, in cells and animal models. Circ Cardiovasc Imaging. 2011 Jul;4(4):435-43. doi: 10.1161/CIRCIMAGING.110.962126. PubMed PMID: 21555377. 3: Gaertner FC, Wiedemann T, Yousefi BH, Lee M, Repokis I, Higuchi T, Nekolla SG, Yu M, Robinson S, Schwaiger M, Pellegata NS. Preclinical evaluation of 18F-LMI1195 for in vivo imaging of pheochromocytoma in the MENX tumor model. J Nucl Med. 2013 Dec;54(12):2111-7. doi: 10.2967/jnumed.113.119966. PubMed PMID: 24136933. 4: Higuchi T, Yousefi BH, Kaiser F, Gärtner F, Rischpler C, Reder S, Yu M, Robinson S, Schwaiger M, Nekolla SG. Assessment of the 18F-labeled PET tracer LMI1195 for imaging norepinephrine handling in rat hearts. J Nucl Med. 2013 Jul;54(7):1142-6. doi: 10.2967/jnumed.112.104232. PubMed PMID: 23670901. 5: Yu M, Bozek J, Kagan M, Guaraldi M, Silva P, Azure M, Onthank D, Robinson SP. Cardiac retention of PET neuronal imaging agent LMI1195 in different species: impact of norepinephrine uptake-1 and -2 transporters. Nucl Med Biol. 2013 Jul;40(5):682-8. doi: 10.1016/j.nucmedbio.2013.03.003. PubMed PMID: 23601914. 6: Yu M, Bozek J, Lamoy M, Kagan M, Benites P, Onthank D, Robinson SP. LMI1195 PET imaging in evaluation of regional cardiac sympathetic denervation and its potential role in antiarrhythmic drug treatment. Eur J Nucl Med Mol Imaging. 2012 Dec;39(12):1910-9. doi: 10.1007/s00259-012-2204-y. PubMed PMID: 22865199. 7: Sinusas AJ, Lazewatsky J, Brunetti J, Heller G, Srivastava A, Liu YH, Sparks R, Puretskiy A, Lin SF, Crane P, Carson RE, Lee LV. Biodistribution and radiation dosimetry of LMI1195: first-in-human study of a novel 18F-labeled tracer for imaging myocardial innervation. J Nucl Med. 2014 Sep;55(9):1445-51. doi: 10.2967/jnumed.114.140137. PubMed PMID: 24994931. 8: Higuchi T, Yousefi BH, Reder S, Beschorner M, Laitinen I, Yu M, Robinson S, Wester HJ, Schwaiger M, Nekolla SG. Myocardial Kinetics of a Novel [(18)F]-Labeled Sympathetic Nerve PET Tracer LMI1195 in the Isolated Perfused Rabbit Heart. JACC Cardiovasc Imaging. 2015 Oct;8(10):1229-31. doi: 10.1016/j.jcmg.2014.11.013. PubMed PMID: 25797132. 9: Rimoldi O. Assessing the activity of cardiac sympathetic innervation with a novel PET tracer. Eur J Nucl Med Mol Imaging. 2012 Dec;39(12):1901-3. doi: 10.1007/s00259-012-2264-z. PubMed PMID: 23081823. 10: Vaidyanathan G, McDougald D, Koumarianou E, Choi J, Hens M, Zalutsky MR. Synthesis and evaluation of 4-[18F]fluoropropoxy-3-iodobenzylguanidine ([18F]FPOIBG): A novel 18F-labeled analogue of MIBG. Nucl Med Biol. 2015 Aug;42(8):673-84. doi: 10.1016/j.nucmedbio.2015.04.005. PubMed PMID: 25956997; PubMed Central PMCID: PMC4481138.