Valtorcitabine dihydrochloride | CAS#359689-54-6 | DNA Polymerase Inhibitor

MedKoo Cat#: 558304 | Name: Valtorcitabine dihydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Valtorcitabine dihydrochloride is a DNA polymerase inhibitor potentially for the treatment of HBV infection.

Chemical Structure

Valtorcitabine dihydrochloride

CAS#359689-54-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 558304

Name: Valtorcitabine dihydrochloride

CAS#: 359689-54-6 (HCl)

Chemical Formula: C14H24Cl2N4O5

Exact Mass:

Molecular Weight: 399.27

Elemental Analysis: C, 42.12; H, 6.06; Cl, 17.76; N, 14.03; O, 20.04

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

359689-54-6 (HCl) 380886-95-3 (free base)

Synonym

LDC-300; LDC300; LDC 300; NM-147; NM147; NM 147 monoVal-L-dC; L-dC; NV-02C; val-L-dC; LdC

IUPAC/Chemical Name

[(2S,3R,5S)-5-(4-amino-2-oxopyrimidin-1-yl)-2-(hydroxymethyl)oxolan-3-yl] (2S)-2-amino-3-methylbutanoate;dihydrochloride

InChi Key

KDDUQKQRHQCADM-KRTNAVHJSA-N

InChi Code

InChI=1S/C14H22N4O5.2ClH/c1-7(2)12(16)13(20)23-8-5-11(22-9(8)6-19)18-4-3-10(15)17-14(18)21;;/h3-4,7-9,11-12,19H,5-6,16H2,1-2H3,(H2,15,17,21);2*1H/t8-,9+,11+,12+;;/m1../s1

SMILES Code

O=C1N=C(N)C=CN1[C@H]2C[C@@H]([C@@H](CO)O2)OC([C@@H](N)C(C)C)=O.[H]Cl.[H]Cl

Appearance

White to off-white solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Related CAS# 380886-95-3(Valtorcitabine) 359689-54-6(Valtorcitabine dihydrochloride)

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 399.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Keeffe EB, Marcellin P. New and emerging treatment of chronic hepatitis B. Clin Gastroenterol Hepatol. 2007 Mar;5(3):285-94. Review. PubMed PMID: 17218162. 2: Gish RG. Clinical trial results of new therapies for HBV: implications for treatment guidelines. Semin Liver Dis. 2005;25 Suppl 1:29-39. Review. PubMed PMID: 16103979. 3: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2005 Jan-Feb;27(1):49-77. PubMed PMID: 15834459. 4: Hodge RA. Telbivudine/Torcitabine Idenix/Novartis. Curr Opin Investig Drugs. 2004 Feb;5(2):232-41. Review. PubMed PMID: 15043399.