SCH-442416 is a selective adenosine A2A receptor antagonist. SCH-442416 binds to human and rat A2A receptors with high affinity (Ki values are 0.048 and 0.5 nM respectively). It displays > 23000-fold selectivity for hA2A over hA1 in vitro with minimal affinity for hA2B and hA3 receptors (IC50 > 10 μM).
MedKoo Cat#: 526323
Name: SCH-442416
CAS#: 316173-57-6
Chemical Formula: C20H19N7O2
Exact Mass: 389.1600
Molecular Weight: 389.42
Elemental Analysis: C, 61.69; H, 4.92; N, 25.18; O, 8.22
Solvent | mg/mL | mM | |
---|---|---|---|
Solubility | |||
DMF | 15.0 | 38.52 | |
DMSO | 10.0 | 25.68 |
The following data is based on the product molecular weight 389.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |