Synonym
ZD-9379; ZD 9379; ZD9379.
IUPAC/Chemical Name
7-Chloro-2,3-dihydro-2-(4-methoxy-2-methylphenyl)pyridazino [4,5-b] quinoline-1,4,10(5H)trione
InChi Key
PSTDMIAVUUYOOQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H14ClN3O4/c1-9-7-11(27-2)4-6-14(9)23-19(26)15-16(18(25)22-23)21-13-8-10(20)3-5-12(13)17(15)24/h3-8H,1-2H3,(H,21,24)(H,22,25)
SMILES Code
O=C1N(C2=CC=C(OC)C=C2C)NC(C(NC3=C4C=CC(Cl)=C3)=C1C4=O)=O
Appearance
White to off-white crystalline powder.
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related CAS#
CAS No.
170142-20-8 (ZD-9379 Free)
170142-29-7 (ZD-9379 sodium)
Preparing Stock Solutions
The following data is based on the
product
molecular weight
383.79
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Danysz W, Parsons CG. Neuroprotective potential of ionotropic glutamate receptor antagonists. Neurotox Res. 2002 Mar;4(2):119-26. doi: 10.1080/10298420290015872. PMID: 12829411.
2: Tatlisumak T, Takano K, Meiler MR, Fisher M. A glycine site antagonist ZD9379 reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion. Acta Neurochir Suppl. 2000;76:331-3. doi: 10.1007/978-3-7091-6346-7_68. PMID: 11450037.
3: ZD 9379. Drugs R D. 1999 Jan;1(1):44-5. doi: 10.2165/00126839-199901010-00018. PMID: 10565985.
4: Tatlisumak T, Takano K, Meiler MR, Fisher M. A glycine site antagonist, ZD9379, reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion. Stroke. 1998 Jan;29(1):190-5. doi: 10.1161/01.str.29.1.190. PMID: 9445350.
5: Qiu H, Hedlund LW, Gewalt SL, Benveniste H, Bare TM, Johnson GA. Progression of a focal ischemic lesion in rat brain during treatment with a novel glycine/NMDA antagonist: an in vivo three-dimensional diffusion-weighted MR microscopy study. J Magn Reson Imaging. 1997 Jul-Aug;7(4):739-44. doi: 10.1002/jmri.1880070421. PMID: 9243396.
6: Takano K, Tatlisumak T, Formato JE, Carano RA, Bergmann AG, Pullan LM, Bare TM, Sotak CH, Fisher M. Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies. Stroke. 1997 Jun;28(6):1255-62; discussion 1263. doi: 10.1161/01.str.28.6.1255. PMID: 9183359.
