Ro 7-0213 is a novel benzodiazepine (Ro7-0213) that contains a quaternary ammonium moiety bearing a full positive charge. RO7-0213 exhibited high affinity for benzodiazepine receptors but acted as an inverse agonist, reducing GABAergic neurotransmission, which contrasts with typical anxiolytic benzodiazepines. In vivo experiments in cats revealed pro-convulsant properties: RO7-0213 induced seizures and produced abnormal EEG patterns characterized by spike-wave discharges, confirming its convulsant activity. These findings highlighted its unique role in studying seizure mechanisms and the functional duality of benzodiazepine receptor ligands, showing receptor binding without anticonvulsant efficacy. RO7-0213 served as a tool to explore the relationship between receptor interaction and neurological outcomes.
MedKoo Cat#: 526218
Name: RO7-0213 chloride
CAS#: 123723-78-4 (cation)
Chemical Formula: C20H23Cl2N3O
Exact Mass: 0.0000
Molecular Weight: 392.32
Elemental Analysis: C, 61.23; H, 5.91; Cl, 18.07; N, 10.71; O, 4.08
The following data is based on the product molecular weight 392.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
