Ro67-4853 is a positive allosteric modulator of mGlu group I receptors (pEC50 value is 7.16 for the rat mGlu1a receptor). Ro67-4853 exhibits activity at all group I receptors, including human and rat mGlu1 and rat mGlu5. It enhances the effects of (S)-DHPG in CA3 neurons (EC50 = 95 nM).
MedKoo Cat#: 532570
Name: Ro67-4853
CAS#: 302841-89-0
Chemical Formula: C19H19NO4
Exact Mass: 325.1314
Molecular Weight: 325.36
Elemental Analysis: C, 70.14; H, 5.89; N, 4.31; O, 19.67
The following data is based on the product molecular weight 325.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
