CT-179 is a highly potent and selective small molecule inhibitor of Olig2 inhibitor. In preclinical studies, CT-179 disrupted OLIG2 transcriptional activity, leading to impaired glioma stem-like cell proliferation and self-renewal. For example, in OLIG2+ patient-derived DIPG cell lines, CT-179 reduced cell viability with IC₅₀ values in the low micromolar range (e.g., ~1–3 μM). In mouse orthotopic xenograft models of DIPG, systemic administration of CT-179 resulted in significant tumor growth inhibition and increased median survival. Additionally, RNA-seq analyses post-treatment showed downregulation of OLIG2-regulated gene networks involved in neural progenitor maintenance and proliferation.
MedKoo Cat#: 413370
Name: CT-179
CAS#: 1996636-69-1
Chemical Formula: C17H22Cl2N6O
Exact Mass: 396.1232
Molecular Weight: 397.30
Elemental Analysis: C, 51.39; H, 5.58; Cl, 17.85; N, 21.15; O, 4.03
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| Soluble in DMSO | 0.0 | 100.00 |
The following data is based on the product molecular weight 397.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
